Department of Nematology, University of California, Riverside, California, United States of America.
Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
PLoS Pathog. 2022 Apr 21;18(4):e1010424. doi: 10.1371/journal.ppat.1010424. eCollection 2022 Apr.
Fatty acid-and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.
脂肪酸和视黄醇结合蛋白 (FARs) 属于排泄/分泌蛋白 (ESPs) 家族中的一个独特家族，仅存在于线虫中。然而，我们对这些蛋白质的了解很大程度上仅限于它们在体外对各种脂肪酸和视黄醇的结合特性，而对其体内功能或机制几乎没有深入了解。然而，最近的研究表明，FARs 在植物和动物模型系统中发挥免疫调节作用，可能是通过隔离参与免疫信号的脂质。这暗示了寄生线虫效应物与其宿主之间的复杂关系。
