Clinic of Neurology, Clinical Center of Vojvodina, Novi Sad, Serbia.
The General Hospital "Dr Radivoj Simonović" Sombor, Serbia.
J Stroke Cerebrovasc Dis. 2022 Jun;31(6):106483. doi: 10.1016/j.jstrokecerebrovasdis.2022.106483. Epub 2022 Apr 4.
The aim of this study was to examine the clinical characteristics of patients with acute ischemic stroke which were previously vaccinated against Coronavirus Disease 2019 (COVID-19) and determine whether the vaccine had impact on outcome.
In this observational cohort study we analyzed the clinical characteristics of 58 patients with ischemic stroke, previously vaccinated against COVID-19. We analyzed demographic characteristics, risk factors, type of stroke and outcome. We also compared outcome of those patients with outcome in stroke patients hospitalized in the same period but not vaccinated, patients hospitalized during the pandemic, before vaccination began, and stroke patients hospitalized before the pandemic. Further, we compared mortality rate with mortality rate in patients who had acute ischemic stroke and COVID-19 simultaneously.
The mean age of the patients was 71.0 years, most were male (58.6%), mostly with risk factors for stroke. In the largest number of patients, 17 (29.3%), the etiopathogenetic mechanism of stroke was atherosclerosis of the large arteries. Mortality in vaccinated patients was identical to mortality in stroke patients before pandemic, without significant difference from mortality in unvaccinated patients (13.8% versus 8.6%; p= 0.23). The mean NIHSS and mRS score at discharge for all examined groups were without significant difference. A significant difference in mortality was found between COVID-19 positive and COVID-19 negative stroke patients (37.8% versus 18.1%; p=0.001).
There are no significant differences in clinical characteristics of stroke in vaccinated compared to unvaccinated patients. We did not find a connection between vaccination and stroke.
本研究旨在探讨先前接种过 2019 年冠状病毒病（COVID-19）疫苗的急性缺血性脑卒中患者的临床特征，并确定疫苗是否对结局有影响。
在这项观察性队列研究中，我们分析了 58 例先前接种过 COVID-19 疫苗的缺血性脑卒中患者的临床特征。我们分析了人口统计学特征、危险因素、脑卒中类型和结局。我们还比较了同期未接种疫苗、接种前大流行期间、大流行前住院的脑卒中患者以及接种前大流行期间住院的脑卒中患者的结局。此外，我们还将死亡率与同时患有急性缺血性脑卒中合并 COVID-19 的患者的死亡率进行了比较。
患者的平均年龄为 71.0 岁，大多数为男性（58.6%），大多数有脑卒中的危险因素。在大多数患者中（17 例，29.3%），脑卒中的病因机制为大动脉粥样硬化。接种疫苗患者的死亡率与大流行前脑卒中患者的死亡率相同，与未接种疫苗患者的死亡率无显著差异（13.8%对 8.6%；p=0.23）。所有检查组的 NIHSS 和 mRS 评分出院时均无显著差异。COVID-19 阳性和 COVID-19 阴性脑卒中患者的死亡率存在显著差异（37.8%对 18.1%；p=0.001）。
与未接种疫苗患者相比，接种疫苗患者的脑卒中临床特征无显著差异。我们未发现疫苗接种与脑卒中之间存在关联。
