Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University,Utrecht, The Netherlands.
Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University,Utrecht, The Netherlands; Charité University, Berlin,Germany.
Psychoneuroendocrinology. 2022 Jul;141:105735. doi: 10.1016/j.psyneuen.2022.105735. Epub 2022 Mar 20.
Stress initiates a cascade of (neuro)biological, physiological, and behavioral changes, allowing us to respond to a challenging environment. The human response to acute stress can be studied in detail in controlled settings, usually in a laboratory environment. To this end, many studies employ acute stress paradigms to probe stress-related outcomes in healthy and patient populations. Though valuable, these studies in themselves often have relatively limited sample sizes. We established a data-sharing and collaborative interdisciplinary initiative, the STRESS-NL database, which combines (neuro)biological, physiological, and behavioral data across many acute stress studies in order to accelerate our understanding of the human acute stress response in health and disease (www.stressdatabase.eu). Researchers in the stress field from 12 Dutch research groups of 6 Dutch universities created a database to achieve an accurate inventory of (neuro)biological, physiological, and behavioral data from laboratory-based human studies that used acute stress tests. Currently, the STRESS-NL database consists of information on 5529 individual participants (2281 females and 3348 males, age range 6-99 years, mean age 27.7 ± 16 years) stemming from 57 experiments described in 42 independent studies. Studies often did not use the same stress paradigm; outcomes were different and measured at different time points. All studies currently included in the database assessed cortisol levels before, during and after experimental stress, but cortisol measurement will not be a strict requirement for future study inclusion. Here, we report on the creation of the STRESS-NL database and infrastructure to illustrate the potential of accumulating and combining existing data to allow meta-analytical, proof-of-principle analyses. The STRESS-NL database creates a framework that enables human stress research to take new avenues in explorative and hypothesis-driven data analyses with high statistical power. Future steps could be to incorporate new studies beyond the borders of the Netherlands; or build similar databases for experimental stress studies in rodents. In our view, there are major scientific benefits in initiating and maintaining such international efforts.
应激会引发一系列（神经）生物学、生理学和行为上的改变，使我们能够对具有挑战性的环境做出反应。人类对急性应激的反应可以在受控环境中进行详细研究，通常是在实验室环境中。为此，许多研究采用急性应激范式来探究健康人群和患者人群中的应激相关结果。虽然这些研究很有价值，但它们本身的样本量通常相对较小。我们建立了一个数据共享和协作的跨学科计划，即 STRESS-NL 数据库，该数据库结合了许多急性应激研究中的（神经）生物学、生理学和行为数据，以加速我们对健康和疾病中人类急性应激反应的理解（www.stressdatabase.eu）。来自荷兰 6 所大学的 12 个荷兰研究小组的应激领域研究人员创建了一个数据库，以准确清点来自使用急性应激测试的实验室人体研究的（神经）生物学、生理学和行为数据。目前，STRESS-NL 数据库包含来自 42 项独立研究中的 57 项实验的信息，涉及 5529 名个体参与者（2281 名女性和 3348 名男性，年龄范围 6-99 岁，平均年龄 27.7±16 岁）。研究通常不使用相同的应激范式；结果不同，测量时间也不同。目前所有纳入数据库的研究都评估了实验性应激前后的皮质醇水平，但皮质醇测量不会成为未来研究纳入的严格要求。在这里，我们报告了 STRESS-NL 数据库的创建和基础设施，以说明积累和组合现有数据以进行元分析、原理验证分析的潜力。STRESS-NL 数据库创建了一个框架，使人类应激研究能够在具有高统计功效的探索性和基于假设的数据分析中开辟新途径。未来的步骤可能是将荷兰以外的新研究纳入其中；或为实验性应激研究在啮齿动物中建立类似的数据库。在我们看来，发起和维持这种国际努力具有重大的科学益处。
