Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia.
School of Medicine, Far Eastern Federal University (FEFU), 690091 Vladivostok, Russia.
Mar Drugs. 2022 Mar 30;20(4):243. doi: 10.3390/md20040243.
Inflammatory reactions are part of a complex biological response that plays a vital role in the appearance of various stimuli resulting from tissue and cell damage, the invasion of pathogenic bacteria, and the formation of the subsequent adaptive immune response. The production of many triggers and mediators of inflammation, which are inducers of pro-inflammatory factors, is controlled by numerous differentiation programs, through which inflammation is resolved and tissue homeostasis is restored. However, prolonged inflammatory responses or dysregulation of pro-inflammatory mechanisms can lead to chronic inflammation. Modern advances in biotechnology have made it possible to characterize the anti-inflammatory activity of phlorotannins, polyphenolic compounds from brown seaweed, and the mechanisms by which they modulate the inflammatory response. The purpose of this review is to analyze and summarize the results of numerous experimental in vitro and in vivo studies, illustrating the regulatory mechanisms of these compounds, which have a wide range of biological effects on the body. The results of these studies and the need for further research are discussed.
炎症反应是一种复杂的生物学反应的一部分，在各种刺激物的出现中起着至关重要的作用，这些刺激物是由组织和细胞损伤、致病细菌的入侵以及随后适应性免疫反应的形成引起的。许多炎症触发因素和介质的产生，即促炎因子的诱导剂，受到许多分化程序的控制，通过这些程序，炎症得到解决，组织内稳态得到恢复。然而，长期的炎症反应或促炎机制的失调可能导致慢性炎症。生物技术的现代进展使得表征来自褐藻的多酚类化合物——岩藻多酚的抗炎活性及其调节炎症反应的机制成为可能。本综述的目的是分析和总结大量体外和体内实验研究的结果，阐明这些化合物的调节机制，这些化合物对人体具有广泛的生物学效应。讨论了这些研究的结果和进一步研究的必要性。
