Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Mar Drugs. 2022 Apr 7;20(4):259. doi: 10.3390/md20040259.
Six new aromatic acids (-) and three new leucine derivatives containing an unusual oxime moiety (-) were isolated and identified from the deep-sea-derived actinomycetes strain SCSIO15079, together with two known compounds (-). The structures of - including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds - were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds and , with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.
从深海来源的放线菌菌株 SCSIO15079 中分离并鉴定了六个新的芳香酸（-）和三个含有不寻常肟部分的新亮氨酸衍生物（-），以及两个已知化合物（-）。通过详细的 NMR、MS 以及实验和计算的电子圆二色谱光谱分析确定了-的结构，包括绝对构型。评估了化合物-的抗菌和细胞毒性活性，以及它们对 HepG2 细胞内脂质积累的影响。化合物-和-具有最强的抑制细胞内脂质积累的活性，在 10 μM 时效果最佳，具有潜在的抗高血脂作用，尽管其机制仍需进一步研究。
