深海底生真菌枝孢属 Cladosporium cladosporioides 170056 中两个新吲哚衍生物 Cladosporioles A 和 B。
Cladosporioles A and B, Two New Indole Derivatives from the Deep-Sea-Derived Fungus Cladosporium cladosporioides 170056.
机构信息
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.
Key Laboratory of Fujian Province for Physiology and Biochemistry of Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen, 361006, China.
出版信息
Chem Biodivers. 2022 Jul;19(7):e202200538. doi: 10.1002/cbdv.202200538. Epub 2022 Jun 30.
Two new (cladosporioles A and B, 1 and 2) and fourteen known (3-16) compounds were isolated from the deep-sea-derived fungus Cladosporium cladosporioides 170056. The relative structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR-ESI-MS spectroscopic data. Their absolute configurations were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. All isolates were tested for antimicrobial activity against Vibrio parahaemolyticus. Compound 15 exhibited weak effect with the MIC value of 156.25 μg/mL.
从深海来源真菌 Cladosporium cladosporioides 170056 中分离得到了两种新化合物（cladosporioles A 和 B，1 和 2）和 14 种已知化合物（3-16）。通过详细分析它们的 NMR 和 HR-ESI-MS 光谱数据，阐明了新化合物的相对结构。通过比较实验和计算的电子圆二色性（ECD）光谱确定了它们的绝对构型。所有分离物均测试了对副溶血弧菌的抗菌活性。化合物 15 表现出较弱的效果，MIC 值为 156.25 μg/mL。
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