Cruciani Alessandro, Motolese Francesco, Todisco Antonio, Di Lazzaro Vincenzo, Assenza Giovanni
Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Brain Sci. 2022 Mar 28;12(4):451. doi: 10.3390/brainsci12040451.
The eight-and-a-half syndrome is a rare neuro-ophthalmological condition caused by a structural lesion in the dorsal portion of the pons, involving critical areas of the brainstem, i.e., medial longitudinal fasciculus (MLF), abducens nucleus, facial genu, and colliculus. It is characterized by internuclear ophthalmoplegia with horizontal gaze palsy and peripheral facial palsy. Although the syndrome is most frequently caused by vascular or demyelinating diseases, several different underlying causes might occur. Herein, we describe a case of the eight-and-a-half syndrome caused by a lung adenocarcinoma metastasis localized in the lower pontine tegmentum. Then, we review the current literature on the underlying causes of the eight-and-a-half syndrome.
八又二分之一综合征是一种罕见的神经眼科疾病，由脑桥背侧的结构性病变引起，累及脑干的关键区域，即内侧纵束（MLF）、展神经核、面神经膝和上丘。其特征为核间性眼肌麻痹伴水平凝视麻痹和周围性面神经麻痹。尽管该综合征最常见的病因是血管性或脱髓鞘疾病，但也可能有几种不同的潜在病因。在此，我们描述一例由肺腺癌转移至脑桥下部被盖区引起的八又二分之一综合征病例。然后，我们回顾了关于八又二分之一综合征潜在病因的当前文献。
