Service de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, France.
GHU Psychiatrie et Neurosciences, Neurochirurgie, F-75014 Paris, France.
Curr Oncol. 2022 Apr 16;29(4):2823-2834. doi: 10.3390/curroncol29040230.
(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture; (2) Material and Methods: volumes, macroscopic volume (MV), brain-adjacent-tumor (BAT) volume and abnormal color-coded DTI volume (aCCV), and region-of-interest samples (probe volumes, ipsi, and contra lateral to the lesion), with their MRI characteristics, apparent diffusion coefficient (ADC), fractional anisotropy (FA) values, and number of fibers (DTI fiber tracking) were analyzed in patients suffering GBM ( = 15) and metastasis ( = 9), and healthy subjects ( = 15), using ad hoc statistical methods (type I error = 5%) (3) Results: GBM volumes were larger than metastasis volumes, aCCV being larger in GBM and BAT ADC was higher in metastasis, ADC decreased centripetally in metastasis, FA increased centripetally either in GBM or metastasis, MV and BAT FA values were higher in GBM, ipsi FA values of GBM ROIs were higher than those of metastasis, and the GBM ipsi number of fibers was higher than the GBM contra number of fibers; (4) Conclusions: The MV, BAT and especially the aCCV, as well as their related water diffusion characteristics, could be useful biomarkers in oncology and functional oncology.
(1) 背景：多形性胶质母细胞瘤（GBM）显示出肿瘤细胞扩散的复杂机制，甚至可以扩散到远处，而这些机制仍知之甚少，因此我们专注于肿瘤和邻近病变的大脑的 MRI 异常，直到对侧半球，特别关注张量扩散成像提供的白质结构信息；(2) 材料和方法：体积、宏观体积（MV）、肿瘤旁（BAT）体积和异常彩色编码 DTI 体积（aCCV），以及感兴趣区样本（探头体积，同侧和对侧病变），及其 MRI 特征、表观扩散系数（ADC）值、各向异性分数（FA）值和纤维数量（DTI 纤维跟踪）在 GBM（=15）和转移瘤（=9）和健康受试者（=15）中进行分析，使用特定的统计方法（错误类型 I = 5%）；(3) 结果：GBM 体积大于转移瘤体积，GBM 的 aCCV 更大，而转移瘤的 BAT ADC 更高，转移瘤的 ADC 向心性降低，GBM 和转移瘤的 FA 向心性增加，MV 和 BAT FA 值在 GBM 中更高，GBM ROI 的同侧 FA 值高于转移瘤，而 GBM 的同侧纤维数量高于对侧纤维数量；(4) 结论：MV、BAT 特别是 aCCV 及其相关的水扩散特征可能是肿瘤学和功能肿瘤学的有用生物标志物。
