Pierce P F, Milhous W K, Campbell C C
Am J Trop Med Hyg. 1987 Jan;36(1):1-2. doi: 10.4269/ajtmh.1987.36.1.
This case of chloroquine prophylaxis failure occurred in the Central African Republic, a country heretofore unaffected by chloroquine resistance. The clinical findings and chloroquine blood levels and blood smears confirmed prophylaxis failure. In vitro susceptibility testing demonstrated the parasite to be 3- to 4-fold more resistant than a susceptible reference clone.
这例氯喹预防失败的病例发生在中非共和国，该国此前未受氯喹耐药性影响。临床症状、氯喹血药浓度及血涂片均证实预防失败。体外药敏试验显示，该疟原虫的耐药性比敏感参照克隆株高3至4倍。
