Meng Zeyu, Chen Huize, Deng Chujun, Meng Shengxi
The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Evid Based Complement Alternat Med. 2022 Apr 11;2022:2464163. doi: 10.1155/2022/2464163. eCollection 2022.
Alzheimer's disease (AD) is a geriatric disease with the morbidity and mortality continuing to grow, partly due to the aging of the world population. As one of the most common types of primary neurodegenerative dementia, it is mainly due to environmental, epigenetic, immunological, and genetic factors. Paeoniflorin (PF), the main component of paeony extract, plays a more and more important role in the prevention and treatment of AD, including regulating protein, anti-inflammation, antioxidation, and antiapoptosis, protecting glial cells, regulating neurotransmitters and related enzymes and receptors, and inhibiting or activating related signal pathways. This article summarizes the latest researches on the multiple effects and the mechanisms of PF in the treatment to cure AD, providing new insights and research basis for further clinical application of traditional Chinese medicine (TCM) in the treatment of AD.
阿尔茨海默病（AD）是一种发病率和死亡率持续上升的老年疾病，部分原因是世界人口老龄化。作为最常见的原发性神经退行性痴呆类型之一，它主要由环境、表观遗传、免疫和遗传因素引起。芍药苷（PF）是芍药提取物的主要成分，在AD的预防和治疗中发挥着越来越重要的作用，包括调节蛋白质、抗炎、抗氧化和抗凋亡、保护神经胶质细胞、调节神经递质及相关酶和受体，以及抑制或激活相关信号通路。本文综述了PF治疗AD的多种作用及机制的最新研究，为中医药在AD治疗中的进一步临床应用提供新的见解和研究依据。
