Koivukangas J, Koivukangas P
Ann Clin Res. 1986;18 Suppl 47:115-24.
Seventeen patients with low-grade cerebral gliomas, fourteen of them low-grade astrocytomas, were operated using CT/ultrasound-guided operative technique. The mean age of the patients was 34 years, and the mean follow-up time 13 months. The patients usually presented with symptoms of headache and/or epilepsy. Craniotomy was performed, and all lesions could be visualized as hyperechogenic masses using intraoperative ultrasound imaging. This paper describes the preliminary results of treatment with conventional resection methods, and discusses methods which could be readily adapted to the CT/ultrasound-based imaging system: CO2 and Nd-YAG laser, ultrasound aspirator, intense focused ultrasound lesioning and immunotherapy with monoclonal antibodies. Finally the evaluation of treatment results with quality of life studies is suggested, especially for longitudinal follow-up of patients treated with alternative therapeutic methods. The role of quality of life studies is particularly important in assuring the longest and most useful survival of patients with small low-grade cerebral tumors.
17例低级别脑胶质瘤患者（其中14例为低级别星形细胞瘤）采用CT/超声引导手术技术进行了手术。患者的平均年龄为34岁，平均随访时间为13个月。患者通常表现为头痛和/或癫痫症状。进行了开颅手术，术中超声成像显示所有病变均为高回声肿块。本文描述了采用传统切除方法的治疗初步结果，并讨论了可轻松应用于基于CT/超声成像系统的方法：二氧化碳和钕钇铝石榴石激光、超声吸引器、高强度聚焦超声毁损以及单克隆抗体免疫治疗。最后建议通过生活质量研究评估治疗结果，特别是对于接受替代治疗方法的患者进行纵向随访。生活质量研究在确保小型低级别脑肿瘤患者获得最长且最有效的生存期方面的作用尤为重要。
