CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University of Strasbourg, ISIS, Strasbourg, 67000, France.
Plateforme Imagerie In Vitro de l'ITI Neurostra, CNRS UAR 3156, University of Strasbourg, Strasbourg, 67000, France.
Small. 2022 May;18(20):e2107652. doi: 10.1002/smll.202107652. Epub 2022 Apr 21.
Human health can be affected by materials indirectly through exposure to the environment or directly through close contact and uptake. With the ever-growing use of 2D materials in many applications such as electronics, medical therapeutics, molecular sensing, and energy storage, it has become more pertinent to investigate their impact on the immune system. Dendritic cells (DCs) are highly important, considering their role as the main link between the innate and the adaptive immune system. By using primary human DCs, it is shown that hexagonal boron nitride (hBN), graphene oxide (GO) and molybdenum disulphide have minimal effects on viability. In particular, it is evidenced that hBN and GO increase DC maturation, while GO leads to the release of reactive oxygen species and pro-inflammatory cytokines. hBN and MoS increase T cell proliferation with and without the presence of DCs. hBN in particular does not show any sign of downstream T cell polarization. The study allows ranking of the three materials in terms of inherent toxicity, providing the following trend: GO > hBN ≈ MoS , with GO the most cytotoxic.
人类健康可能会通过接触环境而间接受到材料的影响，也可能会通过密切接触和吸收而直接受到影响。由于二维材料在电子、医疗治疗、分子传感和能量存储等许多应用中的使用越来越多，研究它们对免疫系统的影响变得尤为重要。树突状细胞 (DCs) 非常重要，因为它们是先天免疫系统和适应性免疫系统之间的主要联系。通过使用原代人 DCs，研究表明六方氮化硼 (hBN)、氧化石墨烯 (GO) 和二硫化钼对细胞活力几乎没有影响。特别是，有证据表明 hBN 和 GO 会增加 DC 的成熟度，而 GO 会导致活性氧和促炎细胞因子的释放。hBN 和 MoS 会在有和没有 DCs 的情况下增加 T 细胞的增殖。特别是 hBN 没有表现出任何下游 T 细胞极化的迹象。该研究根据固有毒性对三种材料进行了排序，给出了以下趋势：GO > hBN ≈ MoS ，其中 GO 的细胞毒性最大。
