Federal State Budget Scientific Institution "Institute of Experimental Medicine", St. Petersburg, Russia.
Birth Defects Res. 2022 Nov 15;114(19):1199-1209. doi: 10.1002/bdr2.2017. Epub 2022 Apr 22.
The main objective of this review was to state a hypothetical mechanism of the antitoxic effect of lactoferrin (Lf) on embryos exposed to bisphenol A (BPA). On this basis, it is possible to suggest Lf as a potential protective health component before conception upon toxic effects and viral infections.
The narrative review was performed using systematic review methods to identify relevant literature. The resources required for this study were obtained by searching the electronic database PubMed (MEDLINE). Articles were searched using the keywords "BPA," "lactoferrin," "DNA-methylation," "epigenetic," "mammals," "human," and "mouse." The inclusion criteria were as follows: (a) primary or original research; (b) study of epigenetic modification; and (c) study focuses on early mammalian development.
Presented data demonstrate that Lf can modulate epigenetical characteristic, such as DNA methylation and reactive oxygen species (ROS), and, thereby, may serve as a potential readily available pharmaceutical product.
Suggested hypothesis is based on the important interrelated role of changes in epigenetic modifications and oxidative stress in early embryogenesis under the influence of BPA and virus infection as a cause of the development of pathologies in the adult organism.
本综述的主要目的是阐述乳铁蛋白（Lf）对暴露于双酚 A（BPA）的胚胎的解毒作用的假设机制。在此基础上，可以提出 Lf 在受孕前作为一种针对毒性作用和病毒感染的潜在保护健康成分。
采用系统评价方法进行叙述性综述，以确定相关文献。本研究所需的资源通过搜索电子数据库 PubMed（MEDLINE）获得。使用关键词“BPA”、“乳铁蛋白”、“DNA 甲基化”、“表观遗传”、“哺乳动物”、“人”和“鼠”搜索文章。纳入标准如下：（a）主要或原始研究；（b）研究表观遗传修饰；（c）研究重点是早期哺乳动物发育。
目前的数据表明，Lf 可以调节表观遗传特征，如 DNA 甲基化和活性氧（ROS），因此，它可能成为一种潜在的现成药物。
所提出的假设基于 BPA 和病毒感染影响下早期胚胎发生中表观遗传修饰和氧化应激变化的重要相互关系，以及它们作为成年机体中病理发展原因的作用。
