Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, Jiangxi, China.
Department of General Practice, The Second Affiliated Hospital, Nanchang University, Nanchang, 330008, Jiangxi, China.
Clin Exp Med. 2023 Jun;23(2):437-445. doi: 10.1007/s10238-022-00822-3. Epub 2022 Apr 22.
To explore the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC). From January 1, 2011 to January 1, 2021, GC patients under 30 years old treated in three tertiary hospitals were enrolled. Clinicopathological characteristics were summarized, prognostic factors and survival outcomes including overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were retrospectively analyzed. One hundred patients were finally included, with a median age of 23 years.73 (73.0%) were female. Most patients had initial symptoms of abdominal pain (66.0%). The most common tumor locations were gastric antrum (38.0%) and gastric body (37.0%). The main histological types were diffuse (81.0%) and poorly differentiated (91.0%). Most patients presented with stage III-IV disease (82.0%) at diagnosis and the common sites of metastasis were ovary (39.5%) and peritoneum (27.6%). The mOS of the whole group was 23.3 months (95% CI 17.2-29.4). Moreover, the mOS of patients at stage I-II was not reached. The mOS of patients at stage III and stage IV was 40.6 months (95% CI 10.2-70.9) and 10.3 months (95% CI 8.9-11.6), respectively. The mDFS of stage I-III patients was 28.5 months (95% CI 14.7-42.3), and the mPFS of the metastatic patients was 4.5 months (95% CI 4.0-5.0). TNM stage (P = 0.005) and radical surgery (P = 0.001) were independent prognostic factors of overall survival. The very young GC were predominantly female, diffuse type, and advanced diagnosis. TNM stage and radical surgery were independent prognosis factors for overall survival.
探讨非常年轻的胃癌（GC）的临床病理特征、生存结局和预后。从 2011 年 1 月 1 日至 2021 年 1 月 1 日，在三家三级医院接受治疗的年龄在 30 岁以下的 GC 患者被纳入本研究。总结临床病理特征，回顾性分析包括总生存期（OS）、无病生存期（DFS）和无进展生存期（PFS）在内的预后因素和生存结局。最终纳入 100 例患者，中位年龄 23 岁，73（73.0%）例为女性。大多数患者最初有腹痛症状（66.0%）。最常见的肿瘤部位是胃窦（38.0%）和胃体（37.0%）。主要组织学类型为弥漫型（81.0%）和低分化型（91.0%）。大多数患者诊断时为 III-IV 期疾病（82.0%），常见转移部位为卵巢（39.5%）和腹膜（27.6%）。全组患者的 mOS 为 23.3 个月（95%CI 17.2-29.4）。此外，I-II 期患者的 mOS 未达到。III 期和 IV 期患者的 mOS 分别为 40.6 个月（95%CI 10.2-70.9）和 10.3 个月（95%CI 8.9-11.6）。I-III 期患者的 mDFS 为 28.5 个月（95%CI 14.7-42.3），转移性患者的 mPFS 为 4.5 个月（95%CI 4.0-5.0）。TNM 分期（P=0.005）和根治性手术（P=0.001）是总生存的独立预后因素。非常年轻的 GC 主要为女性、弥漫型和晚期诊断。TNM 分期和根治性手术是总生存的独立预后因素。
