College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210023, China.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Angew Chem Int Ed Engl. 2022 Jul 4;61(27):e202201101. doi: 10.1002/anie.202201101. Epub 2022 May 5.
Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly effective disease treatment option. Nanozymes with multiple antioxidant activities can cope with the diverse ROS environment. However, lack of design strategies and limitation of negative correlation for nanozymes with multiple antioxidant activities hindered their development. To overcome these difficulties, here we used ZnMn O as a model to explore the role of Mn valency at the octahedral site via a valence-engineered strategy, and found that its multiple antioxidant activities are positively correlated with the content of Mn . Therefore, through this strategy, a self-cascading antioxidant nanozyme LiMn O was constructed, and its efficacy was verified at the cellular level and in an inflammatory bowel disease model. This work not only provides guidance for the design of multiple antioxidant nanozymes, but also broadens the biomedical application potential of multiple antioxidant nanozymes.
抗氧化剂治疗策略通过清除活性氧（ROS）是一种非常有效的疾病治疗选择。具有多种抗氧化活性的纳米酶可以应对多种 ROS 环境。然而，缺乏设计策略和纳米酶多种抗氧化活性的负相关限制了它们的发展。为了克服这些困难，我们在这里使用 ZnMn O 作为模型，通过价态工程策略探索八面体位置 Mn 价态的作用，发现其多种抗氧化活性与 Mn 的含量呈正相关。因此，通过该策略构建了自级联抗氧化纳米酶 LiMn O，并在细胞水平和炎症性肠病模型中验证了其疗效。这项工作不仅为多种抗氧化纳米酶的设计提供了指导，而且拓宽了多种抗氧化纳米酶的生物医学应用潜力。
