Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Sci Immunol. 2022 Apr 22;7(70):eabn1889. doi: 10.1126/sciimmunol.abn1889.
The circulating precursor cells that give rise to human resident memory T cells (T) are poorly characterized. We used an in vitro differentiation system and human skin-grafted mice to study T generation from circulating human memory T cell subsets. In vitro T differentiation was associated with functional changes, including enhanced IL-17A production and FOXP3 expression in CD4 T cells and granzyme B production in CD8 T cells, changes that mirrored the phenotype of T cells in healthy human skin. Effector memory T cells (T) had the highest conversion rate to T in vitro and in vivo, but central memory T cells (T) persisted longer in the circulation, entered the skin in larger numbers, and generated increased numbers of T. In summary, T are highly efficient precursors of human skin T, a feature that may underlie their known association with effective long-term immunity.
循环前体细胞是产生人类固有记忆 T 细胞（T）的细胞，但它们的特征尚未被充分描述。我们使用体外分化系统和人皮肤移植小鼠来研究循环中人类记忆 T 细胞亚群的 T 细胞生成。体外 T 细胞分化与功能变化相关，包括 CD4 T 细胞中增强的 IL-17A 产生和 FOXP3 表达，以及 CD8 T 细胞中颗粒酶 B 的产生，这些变化反映了健康人皮肤中 T 细胞的表型。效应记忆 T 细胞（T）在体外和体内向 T 细胞的转化率最高，但中央记忆 T 细胞（T）在循环中持续时间更长，更多地进入皮肤，并产生更多的 T 细胞。总之，T 细胞是人类皮肤 T 细胞的高效前体细胞，这一特征可能是它们与有效长期免疫相关的基础。
