Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Blood Adv. 2018 Feb 13;2(3):292-298. doi: 10.1182/bloodadvances.2017011346.
Central memory T cells (T) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human T vs effector memory T cells (T) from the same donors. In humans, the majority of human T were tropic for either skin or gut, and the overall tissue tropism of T was comparable to that of T T were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for T in the primary immunosurveillance of peripheral tissues. T also had potent effector functions; 80% of CD8 T produced TC1/TC2/TC17/TC22 cytokines. T injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to T-injected mice. In summary, human T express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human T in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.
中央记忆 T 细胞（T）在淋巴结中巡逻，对已知病原体进行中央免疫监视，但尚未被描述为进行主要组织免疫监视。我们分析了来自同一供体的人类 T 与效应记忆 T 细胞（T）中组织归巢地址素的表达。在人类中，大多数 T 细胞对皮肤或肠道具有趋化性，并且 T 的总体组织趋化性与 T 相似。T 存在于健康、非炎症性的人类皮肤、肺、结肠和子宫颈中，表明 T 在周围组织的初级免疫监视中发挥作用。T 还具有强大的效应功能；80%的 CD8 T 产生 TC1/TC2/TC17/TC22 细胞因子。T 注入人皮肤移植小鼠后迁移至皮肤并引起类似于 T 注入小鼠的炎症性发作。总之，人类 T 以类似于其效应记忆对应物的水平表达外周组织归巢受体，存在于健康的人类组织中，具有令人印象深刻的效应功能，并可单独作用于人类移植小鼠诱导皮肤炎症。我们的研究支持人类 T 在周围组织初级免疫监视中的新作用，并强调这种长寿细胞类型在基于组织的免疫反应中的重要作用。
