Ost A, Baroni C D, Biberfeld P, Diebold J, Moragas A, Noël H, Pallesen G, Rácz P, Schipper M, Tenner-Rácz K
Department of Pathology, Karolinska Institute, Stockholm, Sweden.
APMIS Suppl. 1989;8:7-15.
The histological alterations seen in HIV-related lymphadenopathy have been described with different terms by different authors. In order to facilitate comparisons of results from various laboratories, a group of pathologists of the European Lymphoma Study Group (later the European Association for Haematopathology) have proposed a histological classification for the evaluation of HIV related lymphadenopathy. Most observers agree that the morphological and immunohistochemical alterations in the follicles (germinal centres) are the most conspicuous and earliest changes seen. The follicular alterations were therefore used as the basis for the proposed classification. In addition, some features occasionally seen were also included, i.e. angioimmunoblastic hyperplasia, multicentric Castleman-like lesions, and vascular lesions, especially pretumorous and tumorous stages of Kaposi's sarcoma. The proposed classification was used by the members of the group of a collection of lymph nodes compiled from the various centres. The classification was shown to be reproducible and to have clinical relevance in staging of the patients. The prognostic relevance as to the survival of the patients has to be further substantiated by follow-up studies. The proposed classification offers a common terminology for the alterations previously described by different terms by various authors.
不同作者用不同术语描述了在与HIV相关的淋巴结病中所见的组织学改变。为便于比较各实验室的结果，欧洲淋巴瘤研究组（后为欧洲血液病理学协会）的一组病理学家提出了一种用于评估与HIV相关淋巴结病的组织学分类。大多数观察者一致认为，滤泡（生发中心）的形态学和免疫组化改变是最显著且最早出现的变化。因此，滤泡改变被用作所提议分类的基础。此外，还纳入了一些偶尔见到的特征，即血管免疫母细胞增生、多中心Castleman样病变以及血管病变，尤其是卡波西肉瘤的肿瘤前期和肿瘤期。该组成员在对从各个中心收集的一组淋巴结进行研究时采用了所提议的分类。结果表明该分类具有可重复性，且在患者分期方面具有临床相关性。关于患者生存的预后相关性还有待后续研究进一步证实。所提议的分类为先前不同作者用不同术语描述的改变提供了一个通用术语。
