Department of Anesthesiology, The Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, China; Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Biomed Pharmacother. 2022 Jun;150:112983. doi: 10.1016/j.biopha.2022.112983. Epub 2022 Apr 19.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among epilepsy patients, occurring even more frequently in cases with anti-epileptic drug resistance. Despite some advancements in characterizing SUDEP, the underlying mechanism remains incompletely understood. This review summarizes the latest advances in our understanding of the pathogenic mechanisms of SUDEP, in order to identify possible targets for the development of new strategies to prevent SUDEP. Based on our previous research along with the current literature, we focus on the role of sleep-disordered breathing (SDB) and its related neural mechanisms to consider the possible roles of monoaminergic neurons in the modulation of respiration during sleep and the occurrence of SUDEP. Overall, this review suggests that targeting the monoaminergic neurons is a promising approach to preventing SUDEP. The proposed roles of SDB and related monoaminergic neural mechanisms in SUDEP provide new insights for explaining the pathogenesis of SUDEP.
癫痫猝死症（SUDEP）是癫痫患者的主要致死原因，在抗癫痫药物耐药的情况下更为常见。尽管在描述 SUDEP 方面取得了一些进展，但潜在机制仍不完全清楚。本综述总结了我们对 SUDEP 发病机制的最新理解，以确定可能的目标，从而开发新的策略来预防 SUDEP。基于我们之前的研究和当前的文献，我们专注于睡眠障碍性呼吸（SDB）及其相关神经机制的作用，以考虑单胺能神经元在睡眠期间呼吸调节和 SUDEP 发生中的可能作用。总的来说，这篇综述表明，针对单胺能神经元是预防 SUDEP 的一种有前途的方法。SDB 和相关单胺能神经机制在 SUDEP 中的作用为解释 SUDEP 的发病机制提供了新的见解。
