Prieto Jose M, Schinella Guillermo R
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata B1900, Argentina.
Antioxidants (Basel). 2022 Mar 23;11(4):611. doi: 10.3390/antiox11040611.
The relationship between lipid peroxidation and inflammation has been accepted as a paradigm in the field of topical inflammation. The underlying biochemical mechanisms may be summarised as unspecific oxidative damage followed by specific oxidative processes as the physio pathological response in skin tissues. In this experimental review we hypothesise that the characteristics attributed by Traditional Chinese Medicine (TCM) to herbal drugs can be linked to their biomolecular activities within the framework of the above paradigm. To this end, we review and collect experimental data from several TCM herbal drugs to create 2D-3D pharmacological and biochemical spaces that are further reduced to a bidimensional combined space. When multivariate analysis is applied to the latter, it unveils a series of links between TCM herbal characters and the skin lipoperoxidation "Western" model. With the help of these patterns and a focused review on their chemical, pharmacological and antioxidant properties we show that cleansing herbs of bitter and cold nature acting through removal of toxins-including , , and -are highly correlated with strong inhibition of both lipid peroxidation and eicosanoids production. Sweet drugs-such as , and -act through a specific inhibition of the eicosanoids production. The therapeutic value of the remaining drugs-with low antioxidant or anti-inflammatory activity-seems to be based on their actions on the Qi with the exception of furanocoumarin containing herbs- and -which "expel wind". A further observation from our results is that the drugs present in the highly active "Cleansing herbs" cluster are commonly used and may be interchangeable. Our work may pave the way to a translation between two medical systems with radically different philosophies and help the prioritisation of active ingredients with specific biomolecular activities of interest for the treatment of skin conditions.
脂质过氧化与炎症之间的关系已被视为局部炎症领域的一种范例。潜在的生化机制可概括为非特异性氧化损伤，随后是特定的氧化过程，作为皮肤组织中的生理病理反应。在本实验综述中，我们假设中药赋予草药的特性可以在上述范例的框架内与其生物分子活性相关联。为此，我们回顾并收集了几种中药草药的实验数据，以创建二维 - 三维药理学和生化空间，进一步简化为二维组合空间。当对后者应用多变量分析时，它揭示了中药草药特性与皮肤脂质过氧化“西方”模型之间的一系列联系。借助这些模式以及对其化学、药理学和抗氧化特性的重点综述，我们表明，具有苦寒性质、通过排毒（包括大黄、黄连、黄芩和黄柏）起作用的清热草药与脂质过氧化和类花生酸生成的强烈抑制高度相关。甘味药物（如甘草、黄芪和党参）通过特异性抑制类花生酸生成起作用。其余具有低抗氧化或抗炎活性的药物的治疗价值似乎基于它们对气的作用，但含有呋喃香豆素的草药（防风和荆芥）除外，它们“祛风”。我们结果的进一步观察是，高活性“清热草药”组中的药物常用且可能可相互替代。我们的工作可能为两种哲学截然不同的医学体系之间的转化铺平道路，并有助于确定对治疗皮肤疾病具有特定生物分子活性的活性成分的优先级。
