• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多糖通过调节人皮肤成纤维细胞中的基质金属蛋白酶来预防紫外线A诱导的光老化。

Polysaccharides Protect against Ultraviolet A-Induced Photoaging by Regulating Matrix Metalloproteinases in Human Dermal Fibroblasts.

作者信息

Lin His, Cheng Kuan-Chen, Lin Jer-An, Hsieh Liang-Po, Chou Chun-Hsu, Wang Yu-Ying, Lai Ping-Shan, Chu Po-Cheng, Hsieh Chang-Wei

机构信息

Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, South Dist., Taichung City 40227, Taiwan.

Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.

出版信息

Antioxidants (Basel). 2022 Apr 8;11(4):739. doi: 10.3390/antiox11040739.

DOI:10.3390/antiox11040739
PMID:35453423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9029720/
Abstract

Ultraviolet-A (UVA) exposure is a major cause of skin aging and can induce oxidative damage and accelerate skin wrinkling. Many natural polysaccharides exhibit a UV protective effect. In research on polysaccharides (PNPs), a natural macromolecular polysaccharide (4.4-333.487 kDa), studies have shown that PNPs can significantly decrease elastase activity to protect against UVA-induced aging in Hs68 human dermal fibroblasts. Cellular experiments in the present study indicated that PNPs can protect against UVA-induced oxidative damage in Hs68 cells by inhibiting the production of reactive oxygen species. Furthermore, PNPs significantly attenuated UVA-induced cell aging by decreasing the protein expression of matrix metalloproteinase 1, 3, and 9. Pretreatment of Hs68 cells with PNP-40, PNP-60, and PNP-80 before UVA irradiation increased protein expression of tissue inhibitor metalloproteinase 1 by 41%, 42%, and 56% relative to untreated cells. In conclusion, this study demonstrates that PNPs are a natural resource with potentially beneficial effects in protecting against UVA-induced skin aging.

摘要

紫外线A（UVA）照射是皮肤老化的主要原因，可导致氧化损伤并加速皮肤皱纹形成。许多天然多糖具有紫外线防护作用。在对一种天然大分子多糖（4.4 - 333.487 kDa）多糖（PNPs）的研究中，研究表明PNPs可显著降低弹性蛋白酶活性，以防止Hs68人真皮成纤维细胞中UVA诱导的老化。本研究中的细胞实验表明，PNPs可通过抑制活性氧的产生来保护Hs68细胞免受UVA诱导的氧化损伤。此外，PNPs通过降低基质金属蛋白酶1、3和9的蛋白表达，显著减轻了UVA诱导的细胞老化。在UVA照射前用PNP - 40、PNP - 60和PNP - 80预处理Hs68细胞，相对于未处理细胞，组织金属蛋白酶抑制剂1的蛋白表达分别增加了41%、42%和56%。总之，本研究表明PNPs是一种天然资源，在预防UVA诱导的皮肤老化方面可能具有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/c3b116c44d18/antioxidants-11-00739-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/5ba57f452973/antioxidants-11-00739-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/dd5abcd3cb7b/antioxidants-11-00739-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/03cacc5e7015/antioxidants-11-00739-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/d5b544be03e1/antioxidants-11-00739-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/629923037fda/antioxidants-11-00739-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/ec8e94443f9e/antioxidants-11-00739-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/450cc6b5894e/antioxidants-11-00739-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/f2179755b4d2/antioxidants-11-00739-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/c3b116c44d18/antioxidants-11-00739-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/5ba57f452973/antioxidants-11-00739-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/dd5abcd3cb7b/antioxidants-11-00739-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/03cacc5e7015/antioxidants-11-00739-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/d5b544be03e1/antioxidants-11-00739-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/629923037fda/antioxidants-11-00739-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/ec8e94443f9e/antioxidants-11-00739-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/450cc6b5894e/antioxidants-11-00739-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/f2179755b4d2/antioxidants-11-00739-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b58/9029720/c3b116c44d18/antioxidants-11-00739-g009.jpg

相似文献

1
Polysaccharides Protect against Ultraviolet A-Induced Photoaging by Regulating Matrix Metalloproteinases in Human Dermal Fibroblasts.多糖通过调节人皮肤成纤维细胞中的基质金属蛋白酶来预防紫外线A诱导的光老化。
Antioxidants (Basel). 2022 Apr 8;11(4):739. doi: 10.3390/antiox11040739.
2
Effect of Polysaccharides Inhibiting Methylglyoxal-Induced Glycation Damage In Vitro.多糖体外抑制甲基乙二醛诱导的糖基化损伤的作用
Antioxidants (Basel). 2021 Oct 10;10(10):1589. doi: 10.3390/antiox10101589.
3
Dermal Lipogenesis Inhibits Adiponectin Production in Human Dermal Fibroblasts while Exogenous Adiponectin Administration Prevents against UVA-Induced Dermal Matrix Degradation in Human Skin.皮肤脂肪生成抑制人皮肤成纤维细胞中脂联素的产生，而外源性给予脂联素可预防紫外线A诱导的人皮肤真皮基质降解。
Int J Mol Sci. 2016 Jul 14;17(7):1129. doi: 10.3390/ijms17071129.
4
Trans-cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin fibroblasts.反式肉桂酸通过抑制 AP-1 激活和诱导 Nrf2 介导的抗氧化基因来减轻 UVA 诱导的人皮肤成纤维细胞光老化。
J Dermatol Sci. 2018 May;90(2):123-134. doi: 10.1016/j.jdermsci.2018.01.004. Epub 2018 Feb 1.
5
Protective effect of curcumin against ultraviolet A irradiation‑induced photoaging in human dermal fibroblasts.姜黄素对人真皮成纤维细胞中紫外线 A 照射诱导光老化的保护作用。
Mol Med Rep. 2018 May;17(5):7227-7237. doi: 10.3892/mmr.2018.8791. Epub 2018 Mar 20.
6
Handelin Reduces Ultraviolet A-Induced Photoaging by Inhibiting Reactive Oxygen Species Generation and Enhancing Autophagy.汉达林通过抑制活性氧生成和增强自噬来减少紫外线 A 诱导的光老化。
Tohoku J Exp Med. 2023 Feb 17;259(3):189-198. doi: 10.1620/tjem.2022.J108. Epub 2022 Dec 8.
7
Antiphotoaging Effect of 3,5-Dicaffeoyl-epi-quinic Acid against UVA-Induced Skin Damage by Protecting Human Dermal Fibroblasts In Vitro.3,5-二咖啡酰基表奎尼酸通过体外保护人真皮成纤维细胞对抗 UVA 诱导的皮肤损伤的抗光老化作用。
Int J Mol Sci. 2020 Oct 20;21(20):7756. doi: 10.3390/ijms21207756.
8
Rheological properties of polysaccharides from Pholiota nameko with different temperature extraction: Concentration, pH, temperature, and saltion.不同温度提取的香菇多糖的流变性：浓度、pH 值、温度和盐度。
J Food Sci. 2022 Aug;87(8):3632-3643. doi: 10.1111/1750-3841.16223. Epub 2022 Jun 28.
9
Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts.绿原酸通过调节人真皮成纤维细胞胶原代谢和细胞凋亡预防 UVA 诱导的皮肤光老化。
Int J Mol Sci. 2022 Jun 22;23(13):6941. doi: 10.3390/ijms23136941.
10
Physicochemical properties and protective effects on UVA-induced photoaging in Hs68 cells of Pleurotus ostreatus polysaccharides by fractional precipitation.通过分级沉淀法研究平菇多糖的理化性质及其对Hs68细胞中UVA诱导的光老化的保护作用。
Int J Biol Macromol. 2023 Feb 15;228:537-547. doi: 10.1016/j.ijbiomac.2022.12.254. Epub 2022 Dec 27.

引用本文的文献

1
Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.衰老与草药干预：机制洞察与治疗潜力
J Cosmet Dermatol. 2025 Jul;24(7):e70335. doi: 10.1111/jocd.70335.
2
Anti-Inflammatory and Anti-Oxidative Effects of Polysaccharides Extracted from Unripe L. Fruit.未成熟枸杞果实中提取的多糖的抗炎和抗氧化作用
Antioxidants (Basel). 2023 Jul 27;12(8):1506. doi: 10.3390/antiox12081506.

本文引用的文献

1
Hydrogen-Generating Silica Material Prevents UVA-ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents.产氢二氧化硅材料可预防紫外线A诱导的人细胞和3D皮肤等效物中的细胞氧化应激、细胞死亡、胶原蛋白损失和黑色素生成。
Antioxidants (Basel). 2021 Jan 8;10(1):76. doi: 10.3390/antiox10010076.
2
Photoprotective effect of Astragalus membranaceus polysaccharide on UVA-induced damage in HaCaT cells.黄芪多糖对UVA诱导的HaCaT细胞损伤的光保护作用。
PLoS One. 2020 Jul 21;15(7):e0235515. doi: 10.1371/journal.pone.0235515. eCollection 2020.
3
Concentrated growth factor inhibits UVA-induced photoaging in human dermal fibroblasts via the MAPK/AP-1 pathway.
浓缩生长因子通过 MAPK/AP-1 通路抑制 UVA 诱导的人真皮成纤维细胞光老化。
Biosci Rep. 2020 Jul 31;40(7). doi: 10.1042/BSR20193566.
4
Biomarkers, oxidative stress and autophagy in skin aging.皮肤老化中的生物标志物、氧化应激与自噬
Ageing Res Rev. 2020 May;59:101036. doi: 10.1016/j.arr.2020.101036. Epub 2020 Feb 24.
5
Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of ..的抗氧化、抗黑色素生成及抗皱作用
Mycobiology. 2019 Oct 15;47(4):494-505. doi: 10.1080/12298093.2019.1673595. eCollection 2019.
6
Polysaccharides Promotes Cell Proliferation and Migration and Reduces ROS Content in HO-Induced L929 Cells.多糖促进HO诱导的L929细胞的细胞增殖和迁移并降低活性氧含量。
Antioxidants (Basel). 2020 Jan 10;9(1):65. doi: 10.3390/antiox9010065.
7
Environmental Stressors on Skin Aging. Mechanistic Insights.皮肤衰老的环境应激源。机制洞察。
Front Pharmacol. 2019 Jul 9;10:759. doi: 10.3389/fphar.2019.00759. eCollection 2019.
8
Effect of ultrasound-assisted extraction on physicochemical properties and TLR2-affinity binding of the polysaccharides from Pholiota nameko.超声辅助提取对香菇多糖理化性质及 TLR2 亲和性结合的影响。
Int J Biol Macromol. 2019 Aug 15;135:1020-1027. doi: 10.1016/j.ijbiomac.2019.05.177. Epub 2019 May 30.
9
Effects of irradiance on UVA-induced skin aging.光照度对 UVA 诱导皮肤衰老的影响。
J Dermatol Sci. 2019 Apr;94(1):220-228. doi: 10.1016/j.jdermsci.2019.03.005. Epub 2019 Mar 28.
10
Chemical analysis, moisture-preserving, and antioxidant activities of polysaccharides from Pholiota nameko by fractional precipitation.分级沉淀法提取皱盖假芝多糖的化学分析、保水及抗氧化活性研究。
Int J Biol Macromol. 2019 Jun 15;131:1021-1031. doi: 10.1016/j.ijbiomac.2019.03.154. Epub 2019 Mar 22.