Chen Shizhen, Lan Yina, Li Haidong, Xia Liming, Ye Chaohui, Lou Xin, Zhou Xin
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Biomedicines. 2022 Mar 27;10(4):781. doi: 10.3390/biomedicines10040781.
Although the lungs are the primary organ involved, increasing evidence supports the neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigates the potential relationship between coronavirus disease (COVID-19)-related deterioration of brain structure and the degree of damage to lung function. Nine COVID-19 patients were recruited in critical condition from Jin Yin-tan Hospital (Wuhan, China) who had been discharged between 4 February and 27 February 2020. The demographic, clinical, treatment, and laboratory data were extracted from the electronic medical records. All patients underwent chest CT imaging, Xe gas lung MRI, and H brain MRI. Four of the patients were followed up for 8 months. After nearly 12 months of recovery, we found no significant difference in lung ventilation defect percentage (VDP) between the COVID-19 group and the healthy group (3.8 ± 2.1% versus 3.7 ± 2.2%) using Xe MRI, and several lung-function-related parameters-such as gas-blood exchange time (T)-showed improvement (42.2 ms versus 32.5 ms). Combined with H brain MRI, we found that the change in gray matter volume (GMV) was strongly related to the degree of pulmonary function recovery-the greater the increase in GMV, the higher degree of pulmonary function damage.
尽管肺是主要受累器官，但越来越多的证据支持严重急性呼吸综合征冠状病毒2（SARS-CoV-2）具有神经侵袭潜力。本研究调查了冠状病毒病（COVID-19）相关的脑结构恶化与肺功能损害程度之间的潜在关系。从金银潭医院（中国武汉）招募了9例2020年2月4日至2月27日期间出院的危重症COVID-19患者。从电子病历中提取人口统计学、临床、治疗和实验室数据。所有患者均接受了胸部CT成像、氙气肺MRI和头颅MRI检查。其中4例患者进行了8个月的随访。经过近12个月的恢复，我们使用氙气MRI发现COVID-19组与健康组之间的肺通气缺陷百分比（VDP）无显著差异（3.8±2.1%对3.7±2.2%），并且一些与肺功能相关的参数，如气血交换时间（T）有所改善（42.2毫秒对32.5毫秒）。结合头颅MRI，我们发现灰质体积（GMV）的变化与肺功能恢复程度密切相关——GMV增加越大，肺功能损害程度越高。
