Ervolino da Silva Ana Cláudia, de Souza Batista Fábio Roberto, Hassumi Jaqueline Suemi, Pitol Palin Letícia, Monteiro Naara Gabriela, Frigério Paula Buzo, Okamoto Roberta
Department of Diagnosis and Surgery, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015050, SP, Brazil.
Department of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015050, SP, Brazil.
Biology (Basel). 2022 Apr 11;11(4):578. doi: 10.3390/biology11040578.
(1) Background: Postmenopausal osteoporosis combined with an unhealthy lifestyle can lead to the development of metabolic syndrome, a common condition in individuals requiring oral rehabilitation. Bisphosphonates are used to increase bone mineral density. However, further studies are needed to evaluate the action of this drug on the bone repair process in the jaws. The aim of this study was to evaluate the peri-implant repair of rats with estrogen deficiency and metabolic syndrome treated with risedronate sodium. (2) Methods: Twenty-four female Wistar rats were divided into three groups: SHAM: sham surgery; OVX/SM: ovariectomy combined with a cafeteria diet; OVX/SM/RIS: ovariectomy associated with a cafeteria diet and treatment with sodium risedronate. After 30 days, the animals underwent extraction of the upper first molars. Thirty days after the extraction, an implant was installed in the same region. Sixty days after the implant was installed, the animals were euthanized for biomechanical analysis and confocal microscopic analysis. After confirming the normal distribution of the sample data, a one-way ANOVA test was performed, followed by Tukey's post-test, with a 5% significance level. (3) Results: Significant bone preservation was observed in the risedronate-treated group. Higher removal torque values were obtained by the risedronate-treated group. (4) Conclusions: Better biomechanical performance of the implants installed in the animals treated with risedronate sodium was observed.
(1) 背景：绝经后骨质疏松症与不健康的生活方式相结合可导致代谢综合征的发生，这是需要口腔修复的个体中的常见病症。双膦酸盐用于增加骨矿物质密度。然而，需要进一步研究来评估这种药物对颌骨骨修复过程的作用。本研究的目的是评估用利塞膦酸钠治疗的雌激素缺乏和代谢综合征大鼠的种植体周围修复情况。(2) 方法：将24只雌性Wistar大鼠分为三组：假手术组（SHAM）：假手术；卵巢切除/高热量饮食组（OVX/SM）：卵巢切除联合高热量饮食；卵巢切除/高热量饮食/利塞膦酸钠组（OVX/SM/RIS）：卵巢切除联合高热量饮食并接受利塞膦酸钠治疗。30天后，动物接受上颌第一磨牙拔除。拔牙30天后，在同一区域植入种植体。种植体植入60天后，对动物实施安乐死以进行生物力学分析和共聚焦显微镜分析。在确认样本数据呈正态分布后，进行单因素方差分析，随后进行Tukey事后检验，显著性水平为5%。(3) 结果：在利塞膦酸钠治疗组中观察到显著的骨保留。利塞膦酸钠治疗组获得了更高的去除扭矩值。(4) 结论：观察到用利塞膦酸钠治疗的动物中植入的种植体具有更好的生物力学性能。
