Soldati Gino, Prediletto Renato, Demi Marcello, Salvadori Stefano, Pistolesi Massimo
Ippocrate Medical Center, 55032 Lucca, Italy.
Pulmonology Unit, Fondazione Toscana Gabriele Monasterio and National Research Council, 56124 Pisa, Italy.
Diagnostics (Basel). 2022 Apr 11;12(4):952. doi: 10.3390/diagnostics12040952.
For over 15 years, thoracic ultrasound has been applied in the evaluation of numerous lung diseases, demonstrating a variable diagnostic predictive power compared to traditional imaging techniques such as chest radiography and CT. However, in unselected pulmonary patients, there are no rigorous scientific demonstrations of the complementarity of thoracic ultrasound with traditional and standardized imaging techniques that use radiation. In this study 101 unselected pulmonary patients were evaluated blindly with ultrasound chest examinations during their hospital stay. Other instrumental examinations, carried out during hospitalization, were standard chest radiography, computed tomography (CT), and, when needed, radioisotopic investigation and cardiac catheterization. The operator who performed the ultrasound examinations was unaware of the anamnestic and clinical data of the patients. Diffuse fibrosing disease was detected with a sensitivity, specificity and diagnostic accuracy of 100%, 95% and 97%, respectively. In pleural effusions, ultrasound showed a sensitivity, specificity and diagnostic accuracy of 100%. In consolidations, the sensitivity, specificity and diagnostic accuracy were 83%, 98% and 93%, respectively. Low values of sensitivity were recorded for surface nodulations of less than one centimeter. Isolated subpleural ground glass densities were identified as White Lung with a sensitivity of 72% and a specificity of 86%. Only the associations Diffuse ultrasound findings/Definitive fibrosing disease, Ultrasound Consolidation/Definitive consolidation and non-diffuse ultrasound artefactual features/Definitive vascular pathology (pulmonary hypertension, embolism) were statistically significant with adjusted residuals of 7.9, 7 and 4.1, respectively. The obtained results show how chest ultrasound is an effective complementary diagnostic tool for the pulmonologist. When performed, as a complement to the patient's physical examination, it can restrict the diagnostic hypothesis in the case of pleural effusion, consolidation and diffuse fibrosing disease of the lung.
15 年多来,胸部超声已被应用于多种肺部疾病的评估,与传统成像技术如胸部 X 线摄影和 CT 相比,显示出不同的诊断预测能力。然而,在未经挑选的肺部疾病患者中,尚无关于胸部超声与使用辐射的传统标准化成像技术互补性的严格科学论证。在本研究中,对 101 例未经挑选的肺部疾病患者在住院期间进行了胸部超声盲法检查。住院期间进行的其他仪器检查包括标准胸部 X 线摄影、计算机断层扫描(CT),必要时还包括放射性同位素检查和心导管检查。进行超声检查的操作人员不知道患者的既往史和临床资料。弥漫性纤维化疾病的检测灵敏度、特异度和诊断准确率分别为 100%、95%和 97%。在胸腔积液中,超声显示的灵敏度、特异度和诊断准确率均为 100%。在实变中,灵敏度、特异度和诊断准确率分别为 83%、98%和 93%。小于 1 厘米的表面结节的灵敏度值较低。孤立的胸膜下磨玻璃密度影被识别为“白肺”,灵敏度为 72%,特异度为 86%。只有弥漫性超声表现/确诊的纤维化疾病、超声实变/确诊的实变以及非弥漫性超声伪像特征/确诊的血管病变(肺动脉高压、栓塞)之间的关联具有统计学意义,调整后的残差分别为 7.9、7 和 4.1。所得结果表明胸部超声是肺科医生有效的辅助诊断工具。当作为患者体格检查的补充进行时,它可以在胸腔积液、实变和肺部弥漫性纤维化疾病的情况下限制诊断假设。