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基因的 rs8176740 和 rs512770 遗传变异增加了 COVID-19 的风险，以及血小板的血浆浓度。

The rs8176740 and rs512770 Genetic Variants of the Gene Increased the Risk of COVID-19, as well as the Plasma Concentration Platelets.

机构信息

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.

Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.

出版信息

Biomolecules. 2022 Mar 23;12(4):486. doi: 10.3390/biom12040486.

DOI:10.3390/biom12040486
PMID:35454075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9027896/
Abstract

We conducted a case-control study in order to evaluate whether gene polymorphisms were associated with a high risk of developing COVID-19 in a cohort of patients. Six gene polymorphisms (rs651007 /, rs579459 /, rs495828 , rs8176746 , rs8176740 , and rs512770 /) were determined using TaqMan genotyping assays in a group of 415 COVID-19 patients and 288 healthy controls. The distribution of rs651007 /, rs579459 /, rs495828 /, and rs8176746 / polymorphisms was similar in patients and healthy controls. Nonetheless, under co-dominant (OR = 1.89, pC = 6 × 10), recessive (OR = 1.98, pC = 1 × 10), and additive (OR = 1.36, pC = 3 × 10) models, the genotype of the rs8176740 polymorphism increased the risk of developing COVID-19. In the same way, under co-dominant, recessive, and additive models, the genotype of the rs512770 / polymorphism was associated with a high risk of developing COVID-19 (OR = 1.87, pC = 2 × 10; OR = 1.87, pC = 5 × 10; and OR = 1.35, pC = 4 × 10, respectively). On the other hand, the and haplotypes were associated with a high risk of COVID-19 (OR = 5.45, pC = 1 × 10 and OR = 6.33, pC = 1 × 10, respectively). In addition, the rs8176740 genotype was associated with high-platelet plasma concentrations in patients with COVID-19. Our data suggested that the rs512770 and rs8176740 polymorphisms increased the risk of developing COVID-19 and the plasma concentration of platelets.

摘要

我们进行了一项病例对照研究，以评估基因多态性是否与一组患者中 COVID-19 的高发风险相关。在一组 415 名 COVID-19 患者和 288 名健康对照中，使用 TaqMan 基因分型测定法确定了 6 个基因多态性（rs651007/，rs579459/，rs495828/，rs8176746/，rs8176740/和 rs512770/）。患者和健康对照之间 rs651007/，rs579459/，rs495828/和 rs8176746/多态性的分布相似。然而，在共显性（OR=1.89，pC=6×10）、隐性（OR=1.98，pC=1×10）和加性（OR=1.36，pC=3×10）模型下，rs8176740 多态性的基因型增加了患 COVID-19 的风险。同样，在共显性、隐性和加性模型下，rs512770/多态性的基因型与患 COVID-19 的高风险相关（OR=1.87，pC=2×10；OR=1.87，pC=5×10；OR=1.35，pC=4×10）。另一方面，和 haplotypes 与 COVID-19 的高风险相关（OR=5.45，pC=1×10 和 OR=6.33，pC=1×10，分别）。此外，rs8176740 基因型与 COVID-19 患者高血小板血浆浓度相关。我们的数据表明，rs512770 和 rs8176740 多态性增加了患 COVID-19 的风险和血小板的血浆浓度。