Martin A D, Houston C S
CMAJ. 1987 Mar 15;136(6):587-93.
Sales of calcium supplements have increased dramatically since 1983, as middle-aged women seek to prevent or treat bone loss due to osteoporosis. However, epidemiologic studies have failed to support the hypothesis that larger amounts of calcium are associated with increased bone density or a decreased incidence of fractures. The authors examine the evidence from controlled trials on the effects of calcium supplementation and physical activity on bone loss and find that weight-bearing activity, if undertaken early in life and on a regular basis, can increase the peak bone mass of early adulthood, delay the onset of bone loss and reduce the rate of loss. All of these factors will delay the onset of fractures. Carefully planned and supervised physical activity programs can also provide a safe, effective therapy for people who have osteoporosis.
自1983年以来,钙补充剂的销量急剧增长,因为中年女性试图预防或治疗因骨质疏松症导致的骨质流失。然而,流行病学研究未能支持大量补钙与骨密度增加或骨折发生率降低相关的假设。作者审视了关于补钙及体育活动对骨质流失影响的对照试验证据,发现负重活动若在生命早期开始并定期进行,可增加成年早期的峰值骨量,延缓骨质流失的发生并降低流失速率。所有这些因素都将延迟骨折的发生。精心规划和监督的体育活动项目也可为患有骨质疏松症的人提供安全、有效的治疗。