• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The Importance of the Tumor Microenvironment to Understand Tumor Origin, Evolution, and Treatment Response.肿瘤微环境对于理解肿瘤起源、演变及治疗反应的重要性。
Cancers (Basel). 2022 Apr 14;14(8):1983. doi: 10.3390/cancers14081983.
2
[The debate about the origin of venereal disease and VD control in modern China: focusing on Shanghai and Beijing in the first half of the twentieth century].[关于性病起源及近代中国性病防治的争论：以二十世纪上半叶的上海和北京为重点]
Uisahak. 2007 Jun;16(1):1-19.
3
Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy.癌症与癌症免疫治疗中的癌症相关成纤维细胞和肿瘤相关巨噬细胞。
Front Oncol. 2021 May 20;11:668731. doi: 10.3389/fonc.2021.668731. eCollection 2021.
4
The concept of early labour in the experience of maternity in twentieth century Britain.20 世纪英国生育体验中的早期分娩概念。
Midwifery. 2013 Jan;29(1):3-9. doi: 10.1016/j.midw.2012.07.005. Epub 2012 Sep 1.
5
Biological mechanisms linked to inflammation in cancer: Discovery of tumor microenvironment-related biomarkers and their clinical application in solid tumors.与癌症炎症相关的生物学机制：肿瘤微环境相关生物标志物的发现及其在实体瘤中的临床应用。
Int J Biol Markers. 2020 Feb;35(1_suppl):8-11. doi: 10.1177/1724600820906155.
6
Tumor microenvironment differences between primary tumor and brain metastases.原发肿瘤与脑转移瘤之间的肿瘤微环境差异。
J Transl Med. 2020 Jan 3;18(1):1. doi: 10.1186/s12967-019-02189-8.
7
Microenvironment in breast tumorigenesis: Friend or foe?乳腺肿瘤发生中的微环境：朋友还是敌人？
Histol Histopathol. 2019 Jan;34(1):13-24. doi: 10.14670/HH-18-021. Epub 2018 Jul 6.
8
From Halsted to prevention and beyond: advances in the management of breast cancer during the twentieth century.从霍尔斯特德到预防及其他：20世纪乳腺癌治疗的进展
Eur J Cancer. 1999 Dec;35(14):1963-73. doi: 10.1016/s0959-8049(99)00217-8.
9
Beyond the tumour microenvironment.超越肿瘤微环境。
Int J Cancer. 2019 Nov 15;145(10):2611-2618. doi: 10.1002/ijc.32343. Epub 2019 Apr 29.
10
Radiation oncology: a century of achievements.放射肿瘤学：百年成就
Nat Rev Cancer. 2004 Sep;4(9):737-47. doi: 10.1038/nrc1451.

引用本文的文献

1
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.探索诱导多能干细胞在癌症研究和治疗中的广阔前景。
Mol Cancer. 2023 Nov 28;22(1):189. doi: 10.1186/s12943-023-01873-0.

本文引用的文献

1
The Effect of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for Cells Irradiated with Grenz Rays.缺氧对软X射线照射细胞的相对生物效应和氧增强比的影响。
Cancers (Basel). 2022 Feb 28;14(5):1262. doi: 10.3390/cancers14051262.
2
Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes.皮肤微环境在黑色素瘤发生中的作用：表皮角质形成细胞和真皮成纤维细胞促进黑色素细胞中BRAF癌基因诱导的衰老逃逸
Cancers (Basel). 2022 Feb 27;14(5):1233. doi: 10.3390/cancers14051233.
3
Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast Cancer.曲妥珠单抗对肿瘤微环境的调节可使HER2阳性乳腺癌实现放射增敏。
Cancers (Basel). 2022 Feb 17;14(4):1015. doi: 10.3390/cancers14041015.
4
Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment.通过针对骨微环境的新型转化方法推进骨转移的治疗。
Cancers (Basel). 2022 Feb 1;14(3):757. doi: 10.3390/cancers14030757.
5
Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation.小胶质细胞细胞因子通过激活Pyk2和FAK诱导人胶质母细胞瘤的侵袭和增殖。
Cancers (Basel). 2021 Dec 7;13(24):6160. doi: 10.3390/cancers13246160.
6
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment.一种用于创建类人肿瘤微环境的新型原位肝癌模型。
Cancers (Basel). 2021 Aug 8;13(16):3997. doi: 10.3390/cancers13163997.
7
Exploring tissue architecture using spatial transcriptomics.利用空间转录组学探索组织架构。
Nature. 2021 Aug;596(7871):211-220. doi: 10.1038/s41586-021-03634-9. Epub 2021 Aug 11.
8
Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis.表达成纤维细胞活化蛋白的间充质细胞促进胶质母细胞瘤血管生成。
Cancers (Basel). 2021 Jul 1;13(13):3304. doi: 10.3390/cancers13133304.
9
Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress.成骨细胞衍生的旁分泌和自分泌信号保护播散性乳腺癌细胞免受应激。
Cancers (Basel). 2021 Mar 18;13(6):1366. doi: 10.3390/cancers13061366.
10
Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications.用于临床应用开发的腹膜癌病小鼠模型。
Cancers (Basel). 2021 Feb 25;13(5):963. doi: 10.3390/cancers13050963.

肿瘤微环境对于理解肿瘤起源、演变及治疗反应的重要性。

The Importance of the Tumor Microenvironment to Understand Tumor Origin, Evolution, and Treatment Response.

作者信息

Ayuso Jose M, Ochoa Garrido Ignacio

机构信息

Department of Dermatology, University of Wisconsin-Madison, Madison, WI 53705, USA.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.

出版信息

Cancers (Basel). 2022 Apr 14;14(8):1983. doi: 10.3390/cancers14081983.

DOI:10.3390/cancers14081983
PMID:35454888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9030088/
Abstract

During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets [...].

摘要

在二十世纪后半叶，肿瘤学采用了以肿瘤为中心的癌症治疗方法，主要聚焦于肿瘤细胞以确定新的治疗靶点[...]。