戈德布拉特二肾双夹高血压大鼠体内的水和可交换钠

Water and exchangeable sodium in Goldblatt two-kidney, two-clip hypertensive rats.

作者信息

Mac Cormack W P, Rosón M I, Maquieira M K, Méndez M A, Santoro F M, Morera S, de la Riva I J

出版信息

Clin Exp Hypertens A. 1986;8(8):1313-26. doi: 10.3109/10641968609044089.

DOI:10.3109/10641968609044089

Abstract

Exchangeable 22Na (ExNa), total body water (TBW) and the inulin space (InSp) were determined in two-kidney, two-clip (2K-2C) hypertensive and sham operated (normotensive) control rats 6-8 weeks after surgery. TBW (ml/kg lean body weight) was the same in hypertensive and sham rats. In contrast, ExNa (mEq/kglbw) and InSp (ml/kglbw) significantly increased (p less than 0.01) in rats whose hypertension did not exceed 170 mmHg. Consequently, sham, moderate hypertensive (less than 170 mmHg) and severe hypertensive (less than 170 mmHg) animals showed equal TBW but differed in body water distribution in that moderately hypertensive animals displayed a redistribution of water in favor of the extracellular space.

摘要

在术后6 - 8周，对双肾双夹（2K - 2C）高血压大鼠和假手术（正常血压）对照大鼠测定了可交换的22钠（ExNa）、总体水（TBW）和菊粉空间（InSp）。高血压大鼠和假手术大鼠的TBW（毫升/千克瘦体重）相同。相比之下，高血压不超过170 mmHg的大鼠，其ExNa（毫当量/千克瘦体重）和InSp（毫升/千克瘦体重）显著增加（p小于0.01）。因此，假手术组、中度高血压（小于170 mmHg）和重度高血压（小于170 mmHg）动物的TBW相等，但身体水分分布不同，中度高血压动物的水分重新分布有利于细胞外空间。