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戈德布拉特高血压大鼠胸腺细胞中的钠泵活性

Sodium pump activity in thymocytes of rats with Goldblatt hypertension.

作者信息

Mason J C, Poston L, Hilton P J

出版信息

Clin Sci (Lond). 1985 Jan;68(1):11-4. doi: 10.1042/cs0680011.

DOI:10.1042/cs0680011
PMID:3964725
Abstract

Sodium transport has been studied in thymocytes of one-kidney, one-clip (1K, 1C) and two-kidney, one-clip (2K, 1C) models of hypertension in the rat. No differences of intracellular sodium or sodium transport could be demonstrated in either model when compared with sham-operated controls. The experiments provide no evidence to support the concept that an inhibitor of sodium transport is associated with the development of hypertension in the one-kidney, one-clip rat. A previously unrecognized effect of incubation time and cell density on thymocyte sodium metabolism is reported.

摘要

在大鼠高血压的单肾单夹(1K,1C)和双肾单夹(2K,1C)模型的胸腺细胞中研究了钠转运。与假手术对照组相比,在任一模型中均未发现细胞内钠或钠转运的差异。这些实验没有提供证据支持钠转运抑制剂与单肾单夹大鼠高血压发展相关的概念。报告了孵育时间和细胞密度对胸腺细胞钠代谢的一种先前未被认识到的影响。

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