Department of Physiology and Pathophysiology, CancerCare Manitoba Research Institute, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.
Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica do Paraná-PUCPR, Curitiba 80215-901, Brazil.
Cells. 2022 Apr 17;11(8):1368. doi: 10.3390/cells11081368.
Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene expression contribute to a given phenotype. The study of CT in hematological diseases revealed chromosome position as an important factor for specific chromosome translocations. In this review, we highlight the history of CT theory, current knowledge on possible clinical applications of CT analysis, and the impact of CT in the development of hematological neoplasia such as multiple myeloma, leukemia, and lymphomas. Accumulating data on nuclear architecture in cancer allow one to propose the three-dimensional nuclear genomic landscape as a novel cancer biomarker for the future.
染色体在不同的核区域中组织，这些区域被指定为染色体结构域 (CT)。CT 的结构形成是染色质包装和组织的结果，最终影响细胞功能。染色体定位可以识别基因组组织的结构特征，特别是在基因表达变化导致特定表型的疾病中。血液系统疾病中 CT 的研究表明，染色体位置是特定染色体易位的一个重要因素。在这篇综述中，我们强调了 CT 理论的历史、CT 分析可能的临床应用的现有知识，以及 CT 在多发性骨髓瘤、白血病和淋巴瘤等血液系统肿瘤发生发展中的影响。关于癌症中核结构的累积数据使人们能够提出三维核基因组景观作为未来的新型癌症生物标志物。
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