National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Genes (Basel). 2022 Apr 5;13(4):645. doi: 10.3390/genes13040645.
Gene-environment interactions on type 2 diabetes (T2D) risk are studied little among Chinese adults.
This study aimed to explore the interactions among Chinese adults born in early 1960s.
The interaction of single nucleotide polymorphisms (SNPs) and environmental factors on T2D risk were analyzed by multiple linear or logistic regression models, and in total 2216 subjects were included with the age of 49.7 ± 1.5 years.
High dietary intake increased the effects of rs340874 on impaired fasting glucose (IFG), rs5015480, rs7612463 on T2D (OR = 2.27, 2.37, 11.37, respectively), and reduced the effects of rs7172432 on IFG, rs459193 on impaired glucose tolerance (IGT) (OR = 0.08, 0.28, respectively). The associations between rs4607517 and T2D, rs10906115 and IGT, rs4607103, rs5015480 and IFG could be modified by drinking/smoking (OR = 2.28, 0.20, 3.27, 2.58, respectively). Physical activity (PA) interacted with rs12970134, rs2191349, rs4607517 on T2D (OR = 0.39, 3.50, 2.35, respectively), rs2796441 and rs4607517 on IGT (OR = 0.42, 0.33, respectively), and rs4430796, rs5215, and rs972283 on IFG (OR = 0.39, 3.05, 7.96, respectively). Significant interactions were identified between socioeconomic status and rs10830963, rs13266634 on T2D (OR = 0.41, 0.44, respectively), rs1470579 and rs2796441 on IGT (OR = 2.13, 2.37, respectively), and rs7202877 and rs7612463 on IFG (OR = 5.64, 9.18, respectively).
There indeed existed interactions between environmental factors and genetic variants on T2D risk among Chinese adults.
基因-环境相互作用对 2 型糖尿病（T2D）风险的影响在 60 年代出生的中国成年人中研究较少。
本研究旨在探讨中国 60 年代出生的成年人中基因-环境相互作用。
采用多元线性或逻辑回归模型分析单核苷酸多态性（SNP）与环境因素对 T2D 风险的交互作用，共纳入 2216 名年龄为 49.7±1.5 岁的受试者。
高膳食摄入量增加了 rs340874 对空腹血糖受损（IFG）、rs5015480、rs7612463 对 T2D（OR=2.27、2.37、11.37）的影响，降低了 rs7172432 对 IFG、rs459193 对糖耐量受损（IGT）（OR=0.08、0.28）的影响。rs4607517 与 T2D、rs10906115 与 IGT、rs4607103、rs5015480 与 IFG 的关联可被饮酒/吸烟（OR=2.28、0.20、3.27、2.58）所修饰。体力活动（PA）与 rs12970134、rs2191349、rs4607517 对 T2D（OR=0.39、3.50、2.35）、rs2796441 和 rs4607517 对 IGT（OR=0.42、0.33）、rs4430796、rs5215 和 rs972283 对 IFG（OR=0.39、3.05、7.96）的交互作用有影响。社会经济地位与 rs10830963、rs13266634 对 T2D（OR=0.41、0.44）、rs1470579 和 rs2796441 对 IGT（OR=2.13、2.37）、rs7202877 和 rs7612463 对 IFG（OR=5.64、9.18）的交互作用显著。
中国成年人中 T2D 风险确实存在环境因素与遗传变异之间的相互作用。
