Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Nutrients. 2021 Dec 24;14(1):69. doi: 10.3390/nu14010069.
Chile is one of the largest consumers of sugar-sweetened beverages (SSB) world-wide. However, it is unknown whether the effects from this highly industrialized food will mimic those reported in industrialized countries or whether they will be modified by local lifestyle or population genetics. Our goal is to evaluate the interaction effect between SSB intake and T2D susceptibility on fasting glucose. We calculated a weighted genetic risk score (GRSw) based on 16 T2D risk SNPs in 2828 non-diabetic participants of the MAUCO cohort. SSB intake was categorized in four levels using a food frequency questionnaire. Log-fasting glucose was regressed on SSB and GRSw tertiles while accounting for socio-demography, lifestyle, obesity, and Amerindian ancestry. Fasting glucose increased systematically per unit of GRSw (β = 0.02 ± 0.006, = 0.00002) and by SSB intake (β[cat4] = 0.04 ± 0.01, = 0.0001), showing a significant interaction, where the strongest effect was observed in the highest GRSw-tertile and in the highest SSB consumption category (β = 0.05 ± 0.02, = 0.02). SNP-wise, SSB interacted with additive effects of rs7903146 (TCF7L2) (β = 0.05 ± 0.01, 0.002) and with the G/G genotype of rs10830963 (MTNRB1B) (β = 0.19 ± 0.05, = 0.001). Conclusions: The association between SSB intake and fasting glucose in the Chilean population without diabetes is modified by T2D genetic susceptibility.
智利是世界上最大的糖饮料（SSB）消费国之一。然而，目前尚不清楚这种高度工业化的食品的影响是否会与工业化国家报告的影响相似，或者它们是否会因当地生活方式或人口遗传而改变。我们的目标是评估 SSB 摄入量和 T2D 易感性对空腹血糖的交互作用。我们根据 MAUCO 队列中 2828 名非糖尿病患者的 16 个 T2D 风险 SNP 计算了加权遗传风险评分（GRSw）。SSB 摄入量使用食物频率问卷分为四个水平。在考虑社会人口统计学、生活方式、肥胖和美洲原住民血统的情况下，将 SSB 和 GRSw 三分位数回归到空腹血糖。随着 GRSw 的增加，空腹血糖呈系统升高（β=0.02±0.006，=0.00002），随着 SSB 摄入量的增加（β[cat4]=0.04±0.01，=0.0001），表现出显著的交互作用，其中在最高 GRSw 三分位数和最高 SSB 消费类别中观察到最强的作用（β=0.05±0.02，=0.02）。SNP -wise，SSB 与 rs7903146（TCF7L2）的加性效应（β=0.05±0.01，0.002）和 rs10830963（MTNRB1B）的 G/G 基因型（β=0.19±0.05，=0.001）相互作用。结论：在没有糖尿病的智利人群中，SSB 摄入量与空腹血糖之间的关联受 T2D 遗传易感性的影响。
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