Cai Ying, Zhang Luoxin, Zhang Youjian, Lu Rong
Marine College, Shandong University, No. 180 Wenhua West Road, Weihai 264209, China.
Newland Biotechnology Co., Ltd., No. 213 Huoju Road, Weihai 264200, China.
Pharmaceutics. 2022 Apr 8;14(4):822. doi: 10.3390/pharmaceutics14040822.
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the current treatments of IBD are quite limited and are mainly concentrated on the remission of the disease. In addition, the side effects of conventional drugs on the body cannot be ignored. IBD also has a certain relationship with colitis-associated cancer (CAC), and inflammatory cells can produce a large number of tumor-promoting cytokines to promote tumor progression. In recent years, exosomes from plants have been found to have the ability to load drugs to target the intestine and have great potential for the treatment of intestinal diseases. This plant-derived exosome-targeting delivery system can load chemical or nucleic acid drugs and deliver them to intestinal inflammatory sites stably and efficiently. This review summarizes the pathophysiological characteristics of IBD and CAC as well as the application and prospect of plant exosomes in the treatment of IBD and CAC.
炎症性肠病（IBD）是一种慢性复发性肠道疾病，包括克罗恩病（CD）和溃疡性结肠炎（UC）。由于结肠炎病因复杂，目前IBD的治疗方法相当有限，主要集中在疾病的缓解上。此外，传统药物对身体的副作用也不容忽视。IBD还与结肠炎相关癌症（CAC）有一定关系，炎症细胞可产生大量促肿瘤细胞因子促进肿瘤进展。近年来，已发现植物来源的外泌体具有载药靶向肠道的能力，在肠道疾病治疗方面具有巨大潜力。这种植物源外泌体靶向递送系统可以装载化学或核酸药物，并将其稳定、高效地递送至肠道炎症部位。本文综述了IBD和CAC的病理生理特征以及植物外泌体在IBD和CAC治疗中的应用与前景。
