Tsai J J, Shih J T, Lee H L, Wang S R
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1986 May;19(2):118-23.
The bronchoprovocation test has been widely used in diagnosis of bronchial asthma. Forty-eight cases under tentative diagnosis of bronchial asthma, with complaints of cough, shortness of breath, and wheezing, were studied by using histamine and methacholine. Their baseline pulmonary functions were all normal. Among the Fourteen cases, histamine and methacholine provocation tests were both negative in 14 cases (29%) (Group 1). There were 18 cases (37%) of allergic asthmatics with positive challenge to either histamine (2 cases) or methacholine (1 case) or both (15 cases) (Group 2). There were 16 cases (34%) of nonallergic asthmatics with positive challenge to either histamine (2 cases) or methacholine (3 cases) or both (11 cases) (Group 3). In Group 2, the average PD20 FEV1 for methacholine and histamine was 25.8 +/- 8.2 BU and 22.9 +/- 7.1 BU respectively; the average PD25 FEF25-75 for methacholine and histamine was 19.4 +/- 7.0 BU and 21.1 +/- 7.1 BU respectively. The sensitivities, compared between both agents, were nearly the same. In Group 3, the average PD20 FEV1 for methacholine and histamine was 35.1 +/- 9.0 BU and 54.5 +/- 9.6 BU respectively; the average PD25 FEF25-75 for methacholine and histamine was 27.9 +/- 8.6 BU and 50.2 +/- 9.6 BU respectively. Methacholine is more sensitive in detecting airway hyperreactivity in this group. When these two groups of asthmatics were compared, Group 2 patients were more sensitive to challenges with histamine and methacholine (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
支气管激发试验已广泛应用于支气管哮喘的诊断。对48例初步诊断为支气管哮喘、有咳嗽、气短和喘息症状的患者，使用组胺和乙酰甲胆碱进行了研究。他们的基础肺功能均正常。其中，14例（29%）组胺和乙酰甲胆碱激发试验均为阴性（第1组）。有18例（37%）过敏性哮喘患者对组胺（2例）或乙酰甲胆碱（1例）或两者（15例）激发试验呈阳性（第2组）。有16例（34%）非过敏性哮喘患者对组胺（2例）或乙酰甲胆碱（3例）或两者（11例）激发试验呈阳性（第3组）。在第2组中，乙酰甲胆碱和组胺的平均PD20 FEV1分别为25.8±8.2 BU和22.9±7.1 BU；乙酰甲胆碱和组胺的平均PD25 FEF25 - 75分别为19.
