CXCL1 在骨骼、骨髓、肌肉和神经系统的生理学和非癌症疾病中的重要性。

The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System.

机构信息

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland.

Department of Ruminants Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Klemensa Janickiego 29 St., 71-270 Szczecin, Poland.

出版信息

Int J Mol Sci. 2022 Apr 11;23(8):4205. doi: 10.3390/ijms23084205.

This review describes the role of CXCL1, a chemokine crucial in inflammation as a chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases. Due to the vast amount of available information, we focus on the role CXCL1 plays in the physiology of bones, bone marrow, muscle and the nervous system. For this reason, we describe its effects on hematopoietic stem cells, myoblasts, oligodendrocyte progenitors and osteoclast precursors. We also present the involvement of CXCL1 in diseases of selected tissues and organs including Alzheimer's disease, epilepsy, herpes simplex virus type 1 (HSV-1) encephalitis, ischemic stroke, major depression, multiple sclerosis, neuromyelitis optica, neuropathic pain, osteoporosis, prion diseases, rheumatoid arthritis, tick-borne encephalitis (TBE), traumatic spinal cord injury and West Nile fever.

这篇综述描述了趋化因子 CXCL1 的作用，它作为一种趋化因子在炎症中作为中性粒细胞的趋化剂，在生理学和选定的主要非癌症疾病中发挥作用。由于有大量的可用信息，我们专注于 CXCL1 在骨骼、骨髓、肌肉和神经系统生理学中的作用。因此，我们描述了它对造血干细胞、成肌细胞、少突胶质前体细胞和破骨细胞前体的影响。我们还介绍了 CXCL1 在包括阿尔茨海默病、癫痫、单纯疱疹病毒 1 型（HSV-1）脑炎、缺血性中风、重度抑郁症、多发性硬化症、视神经脊髓炎、神经病理性疼痛、骨质疏松症、朊病毒病、类风湿性关节炎、蜱传脑炎（TBE）、创伤性脊髓损伤和西尼罗河热在内的选定组织和器官疾病中的参与。