Service of Endocrinology, University Hospital, Federal University of Maranhão, São Luis 65020-070, Brazil.
Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luis 65020-070, Brazil.
Int J Environ Res Public Health. 2022 Apr 14;19(8):4733. doi: 10.3390/ijerph19084733.
In the COVID-19 pandemic, there was an increase in consultations for precocious puberty. We aim to analyze differences in female puberty before and during the COVID-19 pandemic. A cross-sectional analytical study was designed at the Pediatric Endocrinology Clinic of the University Hospital of the Federal University of Maranhão in São Luis, Brazil. We included 55 girls with precocious puberty, 22 who started puberty during the pandemic and 33 who started puberty before the pandemic. Clinical, anthropometric, laboratory and imaging variables were compared between groups. Statistics were performed to determine if there was a statistical difference between the groups. Girls with puberty during the pandemic had higher Z-scores for weight (1.08 ± 1.29 versus 0.69 ± 0.83; = 0.04), lower ovarian volume (1.88 ± 0.95 versus 3.15 ± 2.31; = 0.01), and smaller differences between thelarche noticed by the parents and the diagnosis (6.63 ± 5.21 versus 12.15 ± 9.96; = 0.02). The association between precocious puberty during the pandemic with higher Z-scores for weight, lower ovarian volume, and a reduction in the time between the perception of pubertal findings by parents and the diagnosis suggests the influence of the pandemic on the normal time of puberty.
在 COVID-19 大流行期间，性早熟咨询有所增加。我们旨在分析 COVID-19 大流行前后女性青春期的差异。本研究在巴西圣路易斯马腊尼昂联邦大学附属医院儿科内分泌科进行了一项横断面分析研究。我们纳入了 55 名性早熟女孩，其中 22 名在大流行期间开始青春期，33 名在大流行前开始青春期。比较了两组之间的临床、人体测量、实验室和影像学变量。进行统计学分析以确定两组之间是否存在统计学差异。在大流行期间开始青春期的女孩体重 Z 评分更高（1.08 ± 1.29 与 0.69 ± 0.83； = 0.04），卵巢体积更小（1.88 ± 0.95 与 3.15 ± 2.31； = 0.01），父母注意到的乳房发育和诊断之间的差异更小（6.63 ± 5.21 与 12.15 ± 9.96； = 0.02）。在大流行期间发生性早熟与体重 Z 评分更高、卵巢体积更小以及父母感知青春期发现与诊断之间的时间减少之间存在关联，这表明大流行对青春期的正常时间有影响。
