Papadimitriou Anastasios, Papadimitriou Dimitrios T
Pediatric Endocrinology Unit, Third Department of Pediatrics, National and Kapodistrian University of Athens, "Attikon" University Hospital, Haidari, 12462 Athens, Greece.
Pediatric-Adolescent Endocrinology and Diabetes, Athens Medical Center, 15125 Marousi, Greece.
Children (Basel). 2021 Jun 10;8(6):492. doi: 10.3390/children8060492.
In recent decades, pubertal onset in girls has been considered to occur at an earlier age than previously. Exposure to endocrine-disrupting chemicals (EDCs) has been associated with alterations in pubertal timing, with several reports suggesting that EDCs may have a role in the secular trend in pubertal maturation, at least in girls. However, relevant studies give inconsistent results. On the other hand, the majority of girls with idiopathic precocious or early puberty present the growth pattern of constitutional advancement of growth (CAG), i.e., growth acceleration soon after birth. Herein, we show that the growth pattern of CAG is unrelated to exposure to endocrine-disrupting chemicals and is the major determinant of precocious or early puberty. Presented data suggest that EDCs, at most, have a minor effect on the timing of pubertal onset in girls.
近几十年来，人们认为女孩青春期的开始年龄比以前更早。接触内分泌干扰化学物质（EDCs）与青春期时间的改变有关，有几份报告表明，EDCs可能至少在女孩青春期成熟的长期趋势中发挥作用。然而，相关研究结果并不一致。另一方面，大多数特发性性早熟或青春期提前的女孩表现出体质性生长加速（CAG）的生长模式，即在出生后不久生长加速。在此，我们表明CAG的生长模式与接触内分泌干扰化学物质无关，是性早熟或青春期提前的主要决定因素。现有数据表明，EDCs对女孩青春期开始时间的影响至多很小。
