锌-钛-铜-钙-磷合金的体外降解性、微观结构评估及生物相容性
In Vitro Degradability, Microstructural Evaluation, and Biocompatibility of Zn-Ti-Cu-Ca-P Alloy.
作者信息
Gopal Navaneethakrishnan, Palaniyandi Parameswaran, Ramasamy Palanisamy, Panchal Hitesh, Ibrahim Ahmed Mohamed Mahmoud, Alsoufi Mohammad S, Elsheikh Ammar H
机构信息
Department of Mechanical Engineering, K. Ramakrishnan College of Technology, Tiruchirappalli 621112, India.
Department of Electrical and Electronics Engineering, SRM Institute of Science and Technology, Chennai 603203, India.
出版信息
Nanomaterials (Basel). 2022 Apr 15;12(8):1357. doi: 10.3390/nano12081357.
According to the modern era, zinc is one of the best replacements for human bio-implants due to its acceptable degradation, nominal degradable rate, and biocompatibility. However, alloying zinc with other nutrient metals is mandatory to improve the mechanical properties. In this research, Zn-4Ti-4Cu was alloyed with calcium and phosphorous through a powder metallurgical process to make guided bone regeneration (GBR). First, the sintering temperature of the alloy was found with the usage of thermogravimetric analysis (TGA). Tensile and compression tests showed the suitability of the alloy in strength. The microstructural characteristics were provided with EDS and SEM. The different phases of the alloy were detected with X-ray diffraction (XRD). We can clearly depict the precipitates formed and the strengthening mechanism due to titanium addition. An electrochemical corrosion (ECM) test was carried out with simulated body fluid (Hank's solution) as the electrolyte. Cytotoxicity, biocompatibility, mechanical properties, and corrosion resistance properties were studied and discussed.
根据现代观点，由于锌具有可接受的降解性、标称降解速率和生物相容性，它是人体生物植入物的最佳替代品之一。然而，将锌与其他营养金属合金化是改善其机械性能的必要手段。在本研究中，通过粉末冶金工艺将Zn-4Ti-4Cu与钙和磷合金化以制造引导性骨再生（GBR）。首先，通过热重分析（TGA）确定合金的烧结温度。拉伸和压缩试验表明该合金强度适宜。通过能谱仪（EDS）和扫描电子显微镜（SEM）对微观结构特征进行了分析。利用X射线衍射（XRD）检测了合金的不同相。我们可以清楚地描绘出形成的析出物以及由于添加钛而产生的强化机制。以模拟体液（汉克氏溶液）为电解质进行了电化学腐蚀（ECM）试验。对细胞毒性、生物相容性、机械性能和耐腐蚀性能进行了研究和讨论。
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