Wang Pei, Gong Yan, Zhou Guangdong, Ren Wenjie, Wang Xiansong
Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Institute of Regenerative Medicine and Orthopedics, Institutes of Health Central Plain, Xinxiang Medical University, Henan 453003, China.
ACS Omega. 2023 Jul 26;8(31):27920-27931. doi: 10.1021/acsomega.3c02727. eCollection 2023 Aug 8.
Bone fractures have always been a burden to patients due to their common occurrence and severe complications. Traditionally, operative treatments have been widely used in the clinic for implanting, despite the fact that they can only achieve bone fixation with limited stability and pose no effect on promoting tissue growth. In addition, the nondegradable implants usually need a secondary surgery for implant removal, otherwise they may block the regeneration of bones resulting in bone nonunion. To overcome the low degradability of implants and avoid multiple surgeries, tissue engineers have investigated various biodegradable materials for bone regeneration, whereas the significance of stability of long-term bone fixation tends to be neglected during this process. Combining the traditional orthopedic implantation surgeries and emerging tissue engineering, we believe that both bone fixation and bone regeneration are indispensable factors for a successful bone repair. Herein, we define such a novel idea as bone regenerative fixation (BRF), which should be the main future development trend of biodegradable materials.
由于骨折的常见性和严重并发症，它一直是患者的负担。传统上，手术治疗在临床上被广泛用于植入，尽管它们只能实现有限稳定性的骨固定，并且对促进组织生长没有作用。此外，不可降解的植入物通常需要二次手术取出，否则它们可能会阻碍骨再生，导致骨不连。为了克服植入物的低降解性并避免多次手术，组织工程师研究了各种用于骨再生的可生物降解材料，然而在此过程中，长期骨固定稳定性的重要性往往被忽视。结合传统的骨科植入手术和新兴的组织工程，我们认为骨固定和骨再生都是成功骨修复不可或缺的因素。在此，我们将这种新想法定义为骨再生固定（BRF），它应该是可生物降解材料未来的主要发展趋势。
