Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Department of Pathology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Nutrients. 2022 Apr 13;14(8):1620. doi: 10.3390/nu14081620.
Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment. Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced kidney damage using a rat model. Rats were randomly assigned to four groups: control, doxorubicin (20 mg/kg, intraperitoneal, i.p.), doxorubicin plus 100 mg/kg of geraniol, and doxorubicin plus 200 mg/kg of geraniol. A single doxorubicin injection triggered kidney impairment, as evidenced by the altered serum creatinine, blood urea nitrogen, and albumin values; it also caused histological changes in the kidney architecture. Additionally, doxorubicin enhanced lipid peroxidation while lowering reduced glutathione, catalase activity, and the expression of glutathione peroxidase and superoxide dismutase. Interestingly, pre-treatment with geraniol rescued doxorubicin-induced alterations in kidney antioxidant parameters, enzymatic activity, and the expression of inflammatory and apoptosis-mediating gene and proteins. Moreover, prophylactic treatment with geraniol preserved most kidney histological characteristics in a dose-dependent manner. These findings support that geraniol could protect against doxorubicin-mediated kidney dysfunction. However, further research is needed to clarify the mechanisms of geraniol's protective effects against doxorubicin-mediated kidney dysfunction.
多柔比星介导的肾脏损伤是癌症治疗中的一个严重问题。因此，本研究采用大鼠模型探讨了香叶醇调节多柔比星诱导的肾脏损伤的能力。大鼠随机分为四组：对照组、多柔比星（20mg/kg，腹腔注射，i.p.）组、多柔比星加 100mg/kg 香叶醇组和多柔比星加 200mg/kg 香叶醇组。单次多柔比星注射引发肾脏损伤，血清肌酐、血尿素氮和白蛋白值的改变证实了这一点；它还导致了肾脏结构的组织学变化。此外，多柔比星增强了脂质过氧化，同时降低了还原型谷胱甘肽、过氧化氢酶活性以及谷胱甘肽过氧化物酶和超氧化物歧化酶的表达。有趣的是，香叶醇预处理挽救了多柔比星诱导的肾脏抗氧化参数、酶活性以及炎症和凋亡介导基因和蛋白的改变。此外，预防性给予香叶醇以剂量依赖的方式保存了大多数肾脏组织学特征。这些发现支持香叶醇可以预防多柔比星介导的肾功能障碍。然而，需要进一步的研究来阐明香叶醇对多柔比星介导的肾脏功能障碍的保护作用机制。
