合成条件对硒纳米粒子抗氧化活性的影响。

The Influence of Synthesis Conditions on the Antioxidant Activity of Selenium Nanoparticles.

机构信息

Heavy Ion Laboratory, University of Warsaw, Pasteura 5A, 02-093 Warsaw, Poland.

Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

出版信息

Molecules. 2022 Apr 12;27(8):2486. doi: 10.3390/molecules27082486.

Selenium nanoparticles (SeNPs) have attracted great attention in recent years due to their unique properties and potential bioactivities. While the production of SeNPs has been long reported, there is little news about the influence of reaction conditions and clean-up procedure on their physical properties (e.g., shape, size) as well as their antioxidant activity. This study takes up this issue. SeNPs were synthesized by two methods using cysteine and ascorbic acid as selenium reductants. The reactions were performed with and without the use of polyvinyl alcohol as a stabilizer. After the synthesis, SeNPs were cleaned using various procedures. The antioxidant properties of the obtained SeNPs were investigated using DPPH and hydroxyl radical scavenging assays. It was found that their antioxidant activity does not always depend only on the nanoparticles size but also on their homogeneity. Moreover, the size and morphology of selenium nanoparticles are controlled by the clean-up step.

硒纳米粒子（SeNPs）由于其独特的性质和潜在的生物活性，近年来引起了极大的关注。虽然硒纳米粒子的生产已经有很长的报道，但关于反应条件和净化程序对其物理性质（如形状、大小）以及抗氧化活性的影响的消息却很少。本研究就针对这一问题展开。本研究使用半胱氨酸和抗坏血酸作为硒还原剂，通过两种方法合成了硒纳米粒子。反应有无聚乙烯醇作为稳定剂进行。合成后，使用各种程序对硒纳米粒子进行净化。采用 DPPH 和羟基自由基清除试验研究了所得硒纳米粒子的抗氧化性质。结果表明，它们的抗氧化活性不仅取决于纳米粒子的大小，还取决于其均一性。此外，硒纳米粒子的尺寸和形态由净化步骤控制。