Schofield R, Lorimore S A, Wright E G
Exp Hematol. 1987 Mar;15(3):217-20.
Marrow from Sl/Sld mice (in which the hemopoietic stromal microenvironment is defective), when implanted beneath the renal capsule of a normal littermate, produces an ectopic marrow site containing the same number of stem cells (CFU-S) and nearly as many GM-CFC as that obtained by implanting marrow from a normal littermate. On the other hand, a marrow plug from an Sl/Sld donor implanted beneath the renal capsule of an Sl/Sld littermate produces less than half the number of CFU-S and about 10% of the number of GM-CFC. This suggests that the recipient of the ectopic implant can contribute in some way to the stromal environment of the grafted marrow.
Sl/Sld小鼠（其造血基质微环境存在缺陷）的骨髓，当植入正常同窝仔鼠的肾被膜下时，会产生一个异位骨髓位点，该位点含有的干细胞（CFU-S）数量与植入正常同窝仔鼠骨髓所获得的干细胞数量相同，GM-CFC数量也几乎一样多。另一方面，将Sl/Sld供体的骨髓块植入Sl/Sld同窝仔鼠的肾被膜下，产生的CFU-S数量不到一半，GM-CFC数量约为10%。这表明异位植入的受体可以以某种方式为移植骨髓的基质环境做出贡献。
