Fritzen T, Marx E, Uy J
Infection. 1986;14 Suppl 4:S293-6. doi: 10.1007/BF01661297.
A randomized, open, prospective study including 45 patients with either soft tissue infections (29 cases) or pneumonia (15 cases) after surgical intervention and one case having both indications was carried out with ofloxacin. The standard dose was 200 mg ofloxacin b. i. d. In most cases, clinical symptoms, such as fever, rubor, swelling and pain in soft tissue infections, as well as fever, dyspnoea, physical and radiological signs for pneumonia, subsided within two to seven days. Laboratory data (blood analyses, liver enzymes) remained in the normal range. The overall tolerability was good. Bacteriological controls have proven that ofloxacin is able to eradicate a broad range of pathogens, including persister pathogens and also certain bacteria like Clostridium perfringens and Erysipelothrix rhusiopathiae. In our study, Streptococcus faecalis was of intermediate sensitivity in one case and resistant in another. Ofloxacin has proven to be effective in soft tissue infections and pneumonia after surgical intervention.
一项随机、开放、前瞻性研究纳入了45例患者，这些患者在外科手术后发生软组织感染（29例）或肺炎（15例），其中1例同时有这两种病症表现。对这些患者使用了氧氟沙星进行治疗。标准剂量为氧氟沙星200mg，每日两次。在大多数病例中，临床症状，如软组织感染时的发热、红肿、肿胀和疼痛，以及肺炎时的发热、呼吸困难、体格检查和影像学表现，在两到七天内消退。实验室数据（血液分析、肝酶）保持在正常范围内。总体耐受性良好。细菌学对照证明，氧氟沙星能够根除多种病原体，包括持续存在的病原体以及某些细菌，如产气荚膜梭菌和猪红斑丹毒丝菌。在我们的研究中，粪肠球菌在1例中为中度敏感，在另1例中耐药。氧氟沙星已被证明在外科手术后的软组织感染和肺炎中有效。
