Ketterl R, Beckurts T, Stübinger B, Claudi B
Chirurgische Klinik und Poliklinik der TU München.
Drugs. 1987;34 Suppl 1:124-30. doi: 10.2165/00003495-198700341-00027.
In an open prospective study, the efficacy and tolerability of ofloxacin in the treatment of chronic post-traumatic osteitis was examined in 83 patients. 103 different pathogens were isolated. More than 75% were Gram-positive bacteria with Staphylococcus aureus occurring in 61% of cases. After ofloxacin treatment bacteriological elimination was more than 90% for both Gram-positive and Gram-negative species, leading to a clinical cure in 85% of patients. Reinfection occurred in 5% of patients. These values were obtained from follow-up examinations which were carried out at least 6 months after the end of therapy. The tolerability of ofloxacin was excellent and no drug-related allergic reactions or side effects were observed. In conjunction with adequate surgical treatment, ofloxacin proved to be a useful antibacterial agent in the therapy of chronic bone infection.
在一项开放性前瞻性研究中，对83例慢性创伤后骨髓炎患者使用氧氟沙星治疗的疗效和耐受性进行了检查。共分离出103种不同病原体。超过75%为革兰氏阳性菌，其中金黄色葡萄球菌占61%。氧氟沙星治疗后，革兰氏阳性菌和革兰氏阴性菌的细菌清除率均超过90%，85%的患者实现临床治愈。5%的患者发生再次感染。这些数据来自治疗结束后至少6个月进行的随访检查。氧氟沙星的耐受性良好，未观察到与药物相关的过敏反应或副作用。与充分的手术治疗相结合，氧氟沙星被证明是治疗慢性骨感染的一种有效抗菌药物。
