Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022 Apr 25;51(2):241-250. doi: 10.3724/zdxbyxb-2021-0297.
Conventional therapies for malignant tumors have limitations and disadvantages. In recent years, the cancer starvation therapy has emerged which intends to deprive cancer cells of nutritional supply. There are several approaches to"starve" cancer cells: to intervene tumor angiogenesis by targeted inhibition of angiogenic factors or their receptors and integrins; to block the blood supply of cancer cells by embolizing or compressing blood vessels; to intervene metabolic process of cancer cells by inhibition of the signal pathways of mitochondrial serine-glycine-one earbon metabolism, glycolysis and amino acid metabolism; cancer starvation therapy can be employed with oxidation therapy, chemotherapy, sonodynamic therapy, anti-autophagy therapy or other therapies to achieve synergistic effects. This article reviews the research progress of cancer starvation therapy in recent years and discusses the existing problems.
恶性肿瘤的传统治疗方法存在局限性和缺点。近年来，出现了一种癌症饥饿疗法，旨在剥夺癌细胞的营养供应。有几种方法可以“饿死”癌细胞：通过靶向抑制血管生成因子或其受体和整合素来干预肿瘤血管生成；通过栓塞或压迫血管来阻断癌细胞的血液供应；通过抑制线粒体丝氨酸-甘氨酸-一碳代谢、糖酵解和氨基酸代谢信号通路来干预癌细胞的代谢过程；癌症饥饿疗法可以与氧化疗法、化疗、声动力学疗法、抗自噬疗法或其他疗法联合使用，以达到协同作用。本文综述了近年来癌症饥饿疗法的研究进展，并讨论了存在的问题。
