Liu W J, Liu D W
Department of Burns and Plastic Surgery, Jiangxi General Hospital of Armed Police, Nanchang 330030,China.
Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Apr 20;38(4):393-399. doi: 10.3760/cma.j.cn501120-20201207-00520.
Extracellular vesicles are nanoparticles secreted by most eukaryotic cells and play important roles in material transport and information transmission between cells, involved in inflammation, angiogenesis, antigen presentation, cell apoptosis, cell differentiation, and other biological processes. The culture supernatant of mesenchymal stem cells is rich in extracellular vesicles, and the extracellular vesicles can regulate the formation of new blood vessels, a key step in wound healing and tissue repair. The persistence of diabetic ulcers is closely related to the blocked formation of wound vascular network. This article reviews the role of extracellular vesicles derived from mesenchymal stem cells in promoting angiogenesis of diabetic ulcers, in order to provide a new idea for the treatment of diabetic ulcers.
细胞外囊泡是大多数真核细胞分泌的纳米颗粒,在细胞间的物质运输和信息传递中发挥重要作用,参与炎症、血管生成、抗原呈递、细胞凋亡、细胞分化等生物学过程。间充质干细胞的培养上清液富含细胞外囊泡,这些细胞外囊泡可调节新血管的形成,这是伤口愈合和组织修复的关键步骤。糖尿病溃疡的持续存在与伤口血管网络形成受阻密切相关。本文综述了间充质干细胞来源的细胞外囊泡在促进糖尿病溃疡血管生成中的作用,以期为糖尿病溃疡的治疗提供新思路。