普里布诺框在大肠杆菌中ompC和ompF基因正向调控中的作用
Roles of the Pribnow box in positive regulation of the ompC and ompF genes in Escherichia coli.
作者信息
Ozawa Y, Mizuno T, Mizushima S
出版信息
J Bacteriol. 1987 Mar;169(3):1331-4. doi: 10.1128/jb.169.3.1331-1334.1987.
Abstract
The roles of the first base of the Pribnow box in positive regulation of the ompC and ompF genes were studied. G- and A-to-T substitutions of the first base of the ompC and ompF Pribnow boxes, respectively, resulted in a high-level functioning of the promoters in the ompR background. The level was further enhanced significantly in the ompR+ background. The effects of other substitutions were also studied. Based on these observations, the roles of the Pribnow box in the positive regulation are discussed.
摘要
研究了Pribnow框第一个碱基在ompC和ompF基因正调控中的作用。分别对ompC和ompF的Pribnow框第一个碱基进行G到A以及A到T的替换，导致在ompR背景下启动子的高水平功能。在ompR+背景下，该水平进一步显著提高。还研究了其他替换的影响。基于这些观察结果，讨论了Pribnow框在正调控中的作用。
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Characterization by deletion mutagenesis in vitro of the promoter region of ompF, a positively regulated gene of Escherichia coli.通过体外缺失诱变对大肠杆菌正调控基因ompF启动子区域的特性分析。
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