Shen Jinze, Wu Yuchen, Ruan Wenjing, Zhu Feng, Duan Shiwei
Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou, China.
Department of Clinical Medicine, The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
Front Oncol. 2022 Apr 7;12:857743. doi: 10.3389/fonc.2022.857743. eCollection 2022.
MiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can inhibit the expression of at least 27 target genes by binding to the 3' untranslated region (3' UTR) of target genes. miR-1908 is involved in the biological processes of cell proliferation, cell differentiation, cell apoptosis, cancer cell invasion, and metastasis. The expression of miR-1908 is regulated by 11 factors, including lncRNA HOTTIP, adipokines (TNF-α, leptin, and resistin), NF-κB, free fatty acid (FFA), cholesterol, stearoyl-CoA desaturase (SCD1), immune-related transcription factors (STAT1, RB1, and IRF1). The expression of miR-1908 is also affected by the anticancer drug OSW-1, growth hormone (GH), and the anticonvulsant drug sodium valproate. In addition, the aberrant expression of miR-1908 is also related to the prognosis of a variety of cancers, including non-small cell lung cancer (NSCLC), ovarian cancer (OC), breast cancer, cervical cancer, glioma, high-grade serous ovarian carcinoma (HGSOC), osteosarcoma, etc. This article summarizes the abnormal expression pattern of miR-1908 in various diseases and its molecular regulation mechanisms. Our work will provide potential hints and direction for future miR-1908-related research.
MiR-1908是一种位于脂肪酸去饱和酶1（FADS1）基因内含子中的微小RNA。在许多疾病如癌症中，MiR-1908的表达水平异常。MiR-1908可通过与靶基因的3'非翻译区（3'UTR）结合来抑制至少27个靶基因的表达。MiR-1908参与细胞增殖、细胞分化、细胞凋亡、癌细胞侵袭和转移等生物学过程。MiR-1908的表达受11种因素调控，包括长链非编码RNA HOTTIP、脂肪因子（肿瘤坏死因子-α、瘦素和抵抗素）、核因子-κB、游离脂肪酸（FFA）、胆固醇、硬脂酰辅酶A去饱和酶（SCD1）、免疫相关转录因子（信号转导和转录激活因子1、视网膜母细胞瘤蛋白1和干扰素调节因子1）。MiR-1908的表达还受抗癌药物OSW-1、生长激素（GH）和抗惊厥药物丙戊酸钠的影响。此外，MiR-1908的异常表达还与多种癌症的预后相关，包括非小细胞肺癌（NSCLC）、卵巢癌（OC）、乳腺癌、宫颈癌、神经胶质瘤、高级别浆液性卵巢癌（HGSOC）、骨肉瘤等。本文总结了MiR-1908在各种疾病中的异常表达模式及其分子调控机制。我们的工作将为未来与MiR-1908相关的研究提供潜在的线索和方向。
