Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Front Cell Infect Microbiol. 2022 Apr 8;12:847716. doi: 10.3389/fcimb.2022.847716. eCollection 2022.
infection is considered a class I carcinogen in the pathogenesis of gastric cancer. In recent years, the interaction relationship between infection and autophagy has attracted increasing attention. Most investigators believe that the pathogenesis of gastric cancer is closely related to the formation of an autophagosome-mediated downstream signaling pathway by infection-induced cells. Autophagy is involved in infection and affects the occurrence and development of gastric cancer. In this paper, the possible mechanism by which infection affects autophagy and the progression of related gastric cancer signaling pathways are reviewed.
感染被认为是胃癌发病机制中的 I 类致癌因素。近年来,感染与自噬之间的相互作用关系引起了越来越多的关注。大多数研究人员认为,胃癌的发病机制与感染诱导细胞形成自噬体介导的下游信号通路密切相关。自噬参与感染,并影响胃癌的发生和发展。本文综述了感染影响自噬和相关胃癌信号通路进展的可能机制。