AP1S1在乳腺癌中的过表达及其临床意义
The Overexpression and Clinical Significance of AP1S1 in Breast Cancer.
作者信息
Zheng Danni, Fu Weida, Jin Lingli, Jiang Xiaofang, Jiang Wenjie, Guan Yaoyao, Hao Rutian
机构信息
Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
出版信息
Cancer Manag Res. 2022 Apr 16;14:1475-1492. doi: 10.2147/CMAR.S346519. eCollection 2022.
PURPOSE
To explore the mechanism of AP1S1 in breast cancer.
METHODS AND RESULTS
In different datasets, we found that AP1S1 is more highly expressed in breast tumors, which was furthermore verified in our local cohort.Immune infiltration analysis showed that AP1S1 was related to a variety of immune cells. The higher AP1S1 expression was negatively correlated with a variety of immune infiltrating cells, suggesting that AP1S1 may affect cellular immunity.Clinical analysis showed that patients with higher AP1S1 expression had higher estrogen receptor gene expression and were more prone to distant metastasis and lymph node metastasis.The overall survival rate, disease-specific survival rate, and progression-free interval time were worse in the group with higher AP1S1 expression. AP1S1 may be a potential oncogene of breast cancer, and overexpression is related to the poor prognosis of breast cancer.Therefore, a nomogram was constructed, along with correlated gene analysis and functional analysis to further explore the carcinogenic mechanism, practical clinical issues, and value of AP1S1.
CONCLUSION
AP1S1 is a potential oncogene of breast cancer.
目的
探讨AP1S1在乳腺癌中的作用机制。
方法与结果
在不同数据集中，我们发现AP1S1在乳腺肿瘤中表达更高，这在我们的本地队列中得到了进一步验证。免疫浸润分析表明，AP1S1与多种免疫细胞有关。AP1S1表达越高，与多种免疫浸润细胞呈负相关，提示AP1S1可能影响细胞免疫。临床分析表明，AP1S1表达较高的患者雌激素受体基因表达较高，更容易发生远处转移和淋巴结转移。AP1S1表达较高的组总体生存率、疾病特异性生存率和无进展间期时间较差。AP1S1可能是乳腺癌的潜在癌基因，其过表达与乳腺癌预后不良有关。因此，构建了列线图，并进行相关基因分析和功能分析，以进一步探讨AP1S1的致癌机制、实际临床问题及价值。
结论
AP1S1是乳腺癌的潜在癌基因。
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